{"id":"W2992673177","doi":"10.1182/blood-2019-128929","title":"Breakthrough Hemolysis in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Ravulizumab: Results of a 52-Week Extension from Two Phase 3 Studies","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Hemoglobinuria; Internal medicine; Adverse effect; Anemia; Surrogate endpoint; Gastroenterology; Surgery; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009653788,0.0003129387,0.0007206211,0.0001274348,0.00006665159,0.000009854875,0.0002046094,0.00008951405,0.0001874366],"category_scores_gemma":[0.00007591574,0.0002123361,0.00008070526,0.0002698375,0.0001601915,0.0001171986,0.00009271296,0.0001489922,0.00008315257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004738845,"about_ca_system_score_gemma":0.00006211342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903535,"about_ca_topic_score_gemma":0.0007436229,"domain_scores_codex":[0.9980854,0.0002509116,0.0006195443,0.0005593621,0.0001248165,0.0003599319],"domain_scores_gemma":[0.9983889,0.0002243795,0.0004189285,0.0005613578,0.0003744861,0.00003198137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02422843,0.007233789,0.9306493,0.0001152112,0.00263437,0.00007922107,0.001690857,0.00004965611,0.03163661,0.00001565313,0.0005714303,0.001095466],"study_design_scores_gemma":[0.3514448,0.008255269,0.5215556,0.001963538,0.00167449,0.00006433627,0.002373256,0.00001476417,0.1112948,0.00006190701,0.0003996342,0.0008975399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967284,0.001363459,0.00000325428,0.00003919168,0.0001203958,0.0007775262,0.0007750096,0.0000487319,0.000144046],"genre_scores_gemma":[0.99878,0.00002243598,0.0001712509,0.00003774967,0.00002075832,0.0000320443,0.0007658913,0.00002547027,0.0001443903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4090937,"threshold_uncertainty_score":0.8658816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303356972150414,"score_gpt":0.257913533737659,"score_spread":0.2448799640161548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}