{"id":"W2992748477","doi":"10.1182/blood.v110.11.161.161","title":"CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Ex vivo; Stem cell; CD34; Severe combined immunodeficiency; Myeloid leukemia; Myeloid; Bone marrow; Cancer research; Immunology; Biology; Leukemia; Homing (biology); In vivo; Molecular biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772472,0.0005143177,0.0003019955,0.0002410974,0.0001405981,0.0002686844,0.0002222095,0.000296138,0.001418561],"category_scores_gemma":[0.00007680456,0.0001727438,0.0002966,0.0001613646,0.0002074572,0.0001554536,0.0001969543,0.0008787132,0.0005102061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368165,"about_ca_system_score_gemma":0.0002603738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693954,"about_ca_topic_score_gemma":0.001219797,"domain_scores_codex":[0.9997954,0.000032112,0.00001581339,0.00003342207,0.00006342588,0.00005989964],"domain_scores_gemma":[0.9999409,0.000009002076,0.00001599769,0.000007043285,0.000006947659,0.0000201498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099741,0.00006773754,0.0001144226,0.00001739734,0.000004771063,0.00001865446,0.000007205053,0.00003213453,0.9984466,0.00005822509,0.0000636668,0.001059198],"study_design_scores_gemma":[0.00005318612,0.0008941293,0.001681106,0.000003955603,0.0000217088,0.0001910696,0.000009524958,0.0007359956,0.9947808,0.00002481261,0.001601616,0.000002079439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936978,0.001068511,0.003274519,0.00009839469,0.00004018418,0.0001029965,0.0002675729,0.0001284898,0.001321463],"genre_scores_gemma":[0.9931517,0.0007011989,0.00308569,0.00005401061,0.00001447144,0.00009390414,0.0007247649,0.00002130683,0.00215293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418561,"threshold_uncertainty_score":0.004745543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377284510432139,"score_gpt":0.2943200173901909,"score_spread":0.2805471722858696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}