{"id":"W2992765543","doi":"10.1101/gad.328468.119","title":"Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Diabetes Research Center; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; European Commission; Achievement Rewards for College Scientists Foundation; National Institutes of Health; Sandler Foundation","keywords":"Euchromatin; Heterochromatin; Biology; Heterochromatin protein 1; Mating of yeast; Subtelomere; Genetics; Nucleosome; Constitutive heterochromatin; Cell biology; Chromatin; Gene; Locus (genetics); Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003058883,0.0002998131,0.0002978707,0.00003229372,0.0002097275,0.0000652321,0.0002060886,0.0001581274,0.00008827395],"category_scores_gemma":[0.00002429242,0.0002897761,0.00006478741,0.00006581899,0.00005751656,0.00001099732,0.0006383447,0.0000783045,0.00005858563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271033,"about_ca_system_score_gemma":0.00007512079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001530746,"about_ca_topic_score_gemma":0.0001106563,"domain_scores_codex":[0.9982923,0.00006480618,0.0003885693,0.0006530458,0.0002113934,0.0003899191],"domain_scores_gemma":[0.9990841,0.00002794111,0.0002020854,0.0004943448,0.00005435355,0.0001372283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003023686,0.00006944616,0.05306537,0.0001774016,0.00005485878,0.000001260926,0.0003121432,0.0000199239,0.9411759,0.000003551935,0.0001778123,0.0049121],"study_design_scores_gemma":[0.0006430534,0.0001346593,0.1140357,0.0000393916,0.0000156806,0.00003110101,0.0001691168,0.001177891,0.8780123,0.00004885119,0.005150004,0.0005422073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998324,0.0006362256,0.0002169389,0.00007368205,0.0000987274,0.0004128792,0.0000327968,0.00002795438,0.0001767455],"genre_scores_gemma":[0.99387,0.0001582768,0.005051124,0.00009308791,0.00003344471,0.00003036366,0.0003608793,0.00003839349,0.0003644423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06316357,"threshold_uncertainty_score":0.9999554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009218439105437664,"score_gpt":0.2160149890431956,"score_spread":0.206796549937758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}