{"id":"W2992765543","doi":"10.1101/gad.328468.119","title":"Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Diabetes Research Center; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; European Commission; Achievement Rewards for College Scientists Foundation; National Institutes of Health; Sandler Foundation","keywords":"Euchromatin; Heterochromatin; Biology; Heterochromatin protein 1; Mating of yeast; Subtelomere; Genetics; Nucleosome; Constitutive heterochromatin; Cell biology; Chromatin; Gene; Locus (genetics); Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007322229,0.0003830052,0.0002079779,0.0001630514,0.0001711503,0.0003136188,0.0003293639,0.0002503662,0.002297468],"category_scores_gemma":[0.00007001738,0.0001630539,0.0002687612,0.0001146984,0.0002692008,0.0001043709,0.0002531921,0.0005656185,0.0004309271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478905,"about_ca_system_score_gemma":0.0002333153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671947,"about_ca_topic_score_gemma":0.001733258,"domain_scores_codex":[0.9998698,0.00001219412,0.000009251265,0.00002831743,0.00004646966,0.00003389789],"domain_scores_gemma":[0.9998887,0.00001424771,0.00003241621,0.00001239773,0.000007932533,0.00004426028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002492052,0.000006998106,0.00006993993,0.00001016429,0.000001546007,0.00001778481,0.000003297095,0.00001952141,0.9994949,0.00003753292,0.00001002151,0.0003032841],"study_design_scores_gemma":[0.000005615098,0.00008912508,0.003325413,0.000002347788,0.000005378355,0.0001371561,0.00001432551,0.0004511114,0.994821,0.00001702285,0.001129542,0.000002107052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958944,0.0006952552,0.001352721,0.0000726623,0.00002225712,0.00001497148,0.0002322087,0.00006939591,0.001646188],"genre_scores_gemma":[0.9931381,0.0002651995,0.001376136,0.00004187714,0.000004480453,0.00001793328,0.0004007816,0.00002642841,0.004729019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002297468,"threshold_uncertainty_score":0.007685781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009218439105437664,"score_gpt":0.2160149890431956,"score_spread":0.206796549937758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}