{"id":"W2992828409","doi":"10.1158/1078-0432.ccr-19-2177","title":"Efficacy and Safety of Dabrafenib in Pediatric Patients with <i>BRAF</i> V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; Brain Tumour Charity","keywords":"Refractory (planetary science); Medicine; Glioma; Dabrafenib; Mutation; Internal medicine; Oncology; Cancer research; Cancer; Biology; Genetics; Gene; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001131208,0.0005524458,0.0009578085,0.0001777799,0.0001840552,0.0005141581,0.0002809037,0.0003640295,0.0007757602],"category_scores_gemma":[0.0009675444,0.0002126496,0.0007324814,0.0003396149,0.0003418227,0.0003477861,0.0001523118,0.001133649,0.0002279014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008788197,"about_ca_system_score_gemma":0.0008475537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043245,"about_ca_topic_score_gemma":0.00235002,"domain_scores_codex":[0.9995688,0.0002220982,0.00003835794,0.00005420657,0.00006684247,0.00004966169],"domain_scores_gemma":[0.999249,0.000161381,0.000279637,0.00005159216,0.00006310212,0.0001951824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.286437,0.01340257,0.3459328,0.001620592,0.004746994,0.001289573,0.0009986855,0.005499105,0.06361436,0.0002662999,0.005944158,0.2702478],"study_design_scores_gemma":[0.09658989,0.2972839,0.5722482,0.0001705438,0.002310765,0.003951586,0.0004004604,0.002772576,0.0147216,0.0001699459,0.009310281,0.00007026786],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964228,0.002340959,0.00015385,0.00008722389,0.000007486838,0.0001234493,0.0003788589,0.00001153581,0.000473671],"genre_scores_gemma":[0.9968917,0.001379005,0.0003263094,0.0001521328,0.0000223314,0.0001066371,0.0009393687,0.000005399665,0.0001772018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131208,"threshold_uncertainty_score":0.006376386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0816485706614812,"score_gpt":0.4617305403487454,"score_spread":0.3800819696872643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}