{"id":"W2992828409","doi":"10.1158/1078-0432.ccr-19-2177","title":"Efficacy and Safety of Dabrafenib in Pediatric Patients with <i>BRAF</i> V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; Brain Tumour Charity","keywords":"Refractory (planetary science); Medicine; Glioma; Dabrafenib; Mutation; Internal medicine; Oncology; Cancer research; Cancer; Biology; Genetics; Gene; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378032,0.0002089327,0.0007298432,0.0003566681,0.00007653259,0.00002397601,0.0001568217,0.0001602244,0.000143092],"category_scores_gemma":[0.001405082,0.0001361407,0.00007381177,0.001094688,0.0002228174,0.0001183175,0.0001374348,0.0007268624,0.00003255276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084283,"about_ca_system_score_gemma":0.0005555151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158705,"about_ca_topic_score_gemma":0.000610734,"domain_scores_codex":[0.9958889,0.0006925713,0.00106702,0.0008490864,0.001086969,0.000415425],"domain_scores_gemma":[0.9930924,0.005223556,0.0002526497,0.0005975946,0.0005063202,0.0003275161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08926941,0.03006273,0.8689591,0.00007472729,0.0002471845,0.0006942721,0.001232839,0.000007051032,0.00009437452,0.000003373822,0.000316103,0.009038857],"study_design_scores_gemma":[0.1501333,0.0141131,0.834466,0.0003324492,0.0001652424,0.000001163251,0.0002587457,0.00001956009,0.0002990052,0.000006316253,0.00008050781,0.0001245699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946336,0.0004992284,4.880858e-7,0.0005344777,0.0001175698,0.003624361,0.0004449152,0.00001711241,0.0001282627],"genre_scores_gemma":[0.9987569,0.0004785066,0.00006536494,0.00005062947,0.0001589654,0.0001640504,0.0002256713,0.00003580027,0.00006410274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06086389,"threshold_uncertainty_score":0.5551658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0816485706614812,"score_gpt":0.4617305403487454,"score_spread":0.3800819696872643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}