{"id":"W2992939848","doi":"10.26508/lsa.201900444","title":"TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"ADAM10; Ectodomain; Tetraspanin; Cell biology; Endocytosis; Endoplasmic reticulum; Alpha secretase; Transmembrane protein; Chemistry; Biology; Metalloproteinase; Amyloid precursor protein; Disintegrin; Cell; Biochemistry; Receptor; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004601376,0.0002132127,0.0003715872,0.0001713068,0.0002038419,0.0001498704,0.0005100698,0.00007908237,0.0009226802],"category_scores_gemma":[0.0008113488,0.0001782226,0.00007373548,0.0009696818,0.0007817235,0.0003056349,0.0003087073,0.0003328019,0.0006379317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000087314,"about_ca_system_score_gemma":0.0007577214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007173264,"about_ca_topic_score_gemma":0.00001978091,"domain_scores_codex":[0.9966365,0.00004060605,0.0003033757,0.0008587571,0.001388058,0.0007727497],"domain_scores_gemma":[0.9978535,0.0001020582,0.00009345202,0.0007823916,0.0002167677,0.000951817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001700622,0.0001327182,0.1106336,0.0001665459,0.00002754433,0.00004513427,0.000212022,0.00001978157,0.8814623,0.001271129,0.001202758,0.004656294],"study_design_scores_gemma":[0.002260834,0.0005916219,0.8810198,0.0002998571,0.00003839645,0.00005975407,0.000236103,0.006623893,0.09059302,0.0001242325,0.01771019,0.0004423578],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887189,0.0006008755,0.0001234042,0.00368876,0.0002803746,0.0005844122,0.000003488781,0.00007820115,0.00592158],"genre_scores_gemma":[0.9866188,0.000508011,0.001775185,0.001575181,0.0001164464,0.00001663215,0.000003318933,0.00002594565,0.009360468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7908694,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392804921950316,"score_gpt":0.3022192136977468,"score_spread":0.2782911644782437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}