{"id":"W2992939848","doi":"10.26508/lsa.201900444","title":"TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"ADAM10; Ectodomain; Tetraspanin; Cell biology; Endocytosis; Endoplasmic reticulum; Alpha secretase; Transmembrane protein; Chemistry; Biology; Metalloproteinase; Amyloid precursor protein; Disintegrin; Cell; Biochemistry; Receptor; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106943,0.0001329253,0.0001138263,0.0001602175,0.0001422683,0.0003362345,0.0001054845,0.0001884606,0.001488491],"category_scores_gemma":[0.0001554764,0.00009556927,0.0001714002,0.0001032759,0.0001690675,0.0002407395,0.0002109752,0.0003207022,0.0004095348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002374,"about_ca_system_score_gemma":0.0001951193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007141583,"about_ca_topic_score_gemma":0.0007265464,"domain_scores_codex":[0.999846,0.00002337479,0.00001329916,0.00002485194,0.00004070254,0.00005179578],"domain_scores_gemma":[0.9998838,0.00001631157,0.0000252708,0.00001075502,0.00002924377,0.00003467736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028125,0.000007081042,0.0004667508,0.000008260925,0.000002465717,0.00004578079,0.00001736932,0.00003176016,0.9985381,0.0001268226,0.00003579148,0.0006169292],"study_design_scores_gemma":[0.0000132455,0.0001076804,0.02507592,0.000004334178,0.00001450873,0.0004550008,0.0001003972,0.001467231,0.9699309,0.0001046579,0.002719839,0.000006334757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978346,0.0004063591,0.0007344285,0.0000372593,0.000009058665,0.000004470776,0.000118355,0.00002156954,0.0008339625],"genre_scores_gemma":[0.997425,0.0002319325,0.0004884209,0.00003030351,0.000003704628,0.000007968101,0.0002162707,0.00001231382,0.001584121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488491,"threshold_uncertainty_score":0.004979432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392804921950316,"score_gpt":0.3022192136977468,"score_spread":0.2782911644782437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}