{"id":"W2992984028","doi":"10.1038/s41590-019-0550-7","title":"Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Israel Science Foundation; Novo Nordisk Fonden; Varda and Boaz Dotan Research Center for Hemato-Oncology Research, Tel Aviv University; American Asthma Foundation","keywords":"Necroptosis; RIPK1; Programmed cell death; Cell biology; Tumor necrosis factor alpha; Biology; Caspase 8; Inflammation; Caspase; Apoptosis; Kinase; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003609785,0.0003818719,0.000481152,0.0002160563,0.0001985191,0.0003774268,0.0003707346,0.0004912391,0.003357799],"category_scores_gemma":[0.0004476204,0.0001874126,0.0003501562,0.0001813183,0.0003198207,0.0003539776,0.0002746879,0.001459412,0.0008722935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003065776,"about_ca_system_score_gemma":0.0004020371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194219,"about_ca_topic_score_gemma":0.0008921471,"domain_scores_codex":[0.9997019,0.00006314776,0.00003665383,0.00004441623,0.00006916797,0.00008471575],"domain_scores_gemma":[0.9998527,0.00002312775,0.00003162561,0.00002742808,0.00001342108,0.00005174419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005456427,0.0005435172,0.0003511017,0.0002910366,0.00007055369,0.0001462301,0.00003685676,0.0005274321,0.9806945,0.0003597522,0.0009311794,0.01059136],"study_design_scores_gemma":[0.001316159,0.003823463,0.005925206,0.00002499962,0.00005526713,0.0007665526,0.00005742036,0.002865262,0.9785295,0.0003034415,0.006313852,0.00001890212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809135,0.006599935,0.004335863,0.0009085995,0.0004548788,0.000107437,0.001201994,0.0003438616,0.005134006],"genre_scores_gemma":[0.9919693,0.001877725,0.00191214,0.0001365354,0.00007227164,0.00005153384,0.0008935741,0.00002639378,0.003060527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003357799,"threshold_uncertainty_score":0.01123297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001478132381201912,"score_gpt":0.199416790538504,"score_spread":0.1979386581573021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}