{"id":"W2992984028","doi":"10.1038/s41590-019-0550-7","title":"Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Israel Science Foundation; Novo Nordisk Fonden; Varda and Boaz Dotan Research Center for Hemato-Oncology Research, Tel Aviv University; American Asthma Foundation","keywords":"Necroptosis; RIPK1; Programmed cell death; Cell biology; Tumor necrosis factor alpha; Biology; Caspase 8; Inflammation; Caspase; Apoptosis; Kinase; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272937,0.0001719432,0.0001616394,0.00007588525,0.00006594803,0.00002066466,0.0001534469,0.0007323762,0.00006775975],"category_scores_gemma":[0.00007665125,0.0001638642,0.00005472872,0.00007098747,0.00007163561,0.00001017544,0.00016027,0.0004115434,0.0001290221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001352966,"about_ca_system_score_gemma":0.00004632126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001267456,"about_ca_topic_score_gemma":0.00003113372,"domain_scores_codex":[0.9990538,0.00006083065,0.000194505,0.0003334892,0.00008913476,0.0002682936],"domain_scores_gemma":[0.9994174,0.00001160138,0.00008960917,0.0003587906,0.00009671083,0.00002586387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001483712,0.00001678698,0.002720273,0.00001465675,0.00008980594,0.00000278276,0.00007509791,0.000006113018,0.9896798,0.0008168797,0.0004093998,0.006020092],"study_design_scores_gemma":[0.001710492,0.0003941046,0.01608192,0.00001476912,0.00001753704,0.00008220683,0.0001891707,0.00001291191,0.8685029,0.0002720779,0.1124199,0.0003020792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984906,0.009395295,0.00001437629,0.0003701556,0.0005474124,0.0002450504,0.000006529363,0.00002054462,0.004494655],"genre_scores_gemma":[0.9964369,0.0006987003,0.00007176713,0.0003401892,0.0001146856,0.00001496454,0.0002057053,0.00002163478,0.002095451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1211769,"threshold_uncertainty_score":0.668219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001478132381201912,"score_gpt":0.199416790538504,"score_spread":0.1979386581573021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}