{"id":"W2993010698","doi":"10.3390/cancers11121964","title":"(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"In vivo; Apoptosis; Cell growth; Cell cycle; Topoisomerase; Chemistry; Cancer research; Growth inhibition; Caspase 3; Cell cycle checkpoint; In vitro; Cell; Molecular biology; Biology; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006737351,0.000205071,0.0002255591,0.0001677373,0.0000802301,0.00009862136,0.0001166532,0.0001472931,0.0009688543],"category_scores_gemma":[0.00007121092,0.00007272731,0.00012302,0.000136788,0.0001278874,0.0000863709,0.00006934353,0.0004403522,0.0001704528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030417,"about_ca_system_score_gemma":0.0002872805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001935833,"about_ca_topic_score_gemma":0.004345288,"domain_scores_codex":[0.999954,0.000007832318,0.000004780409,0.000006112668,0.00001329894,0.00001389614],"domain_scores_gemma":[0.999949,0.000009598706,0.00001000049,0.000007336913,0.000007292387,0.00001682574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004258698,0.0002340644,0.0003693217,0.0001027396,0.000015304,0.00006956099,0.0000137842,0.0001799875,0.9925932,0.00004189433,0.0002017957,0.005752539],"study_design_scores_gemma":[0.00009280797,0.002627285,0.01119544,0.00001034819,0.00002616888,0.0002730881,0.00002916127,0.0009304303,0.9813842,0.00002602274,0.003400557,0.000004515076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908293,0.005617859,0.0005852182,0.000152212,0.00004960001,0.00006186016,0.0004465947,0.0000604017,0.002196873],"genre_scores_gemma":[0.993495,0.003273964,0.0007697737,0.0000672449,0.0000196988,0.00004087511,0.000487015,0.000006243891,0.001840236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935833,"threshold_uncertainty_score":0.003849149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00612509110160536,"score_gpt":0.2162518929092451,"score_spread":0.2101268018076398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}