{"id":"W2993010698","doi":"10.3390/cancers11121964","title":"(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"In vivo; Apoptosis; Cell growth; Cell cycle; Topoisomerase; Chemistry; Cancer research; Growth inhibition; Caspase 3; Cell cycle checkpoint; In vitro; Cell; Molecular biology; Biology; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304464,0.000192999,0.0002112924,0.00009288413,0.00002995464,0.00002040608,0.0001076268,0.0001496967,0.0001205157],"category_scores_gemma":[0.00001028307,0.0002104272,0.00005128875,0.0001298042,0.00003981813,0.000009766578,0.00007137479,0.000129409,0.000007122821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003234676,"about_ca_system_score_gemma":0.0002434915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001343229,"about_ca_topic_score_gemma":0.0005412147,"domain_scores_codex":[0.9989012,0.00005242476,0.0001584845,0.0004473455,0.0001014204,0.000339165],"domain_scores_gemma":[0.999564,0.00002008159,0.00006730638,0.0002196514,0.00002457573,0.0001043848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000746436,0.00002769017,0.001200483,0.00004105064,0.000004735831,0.00001067038,0.0001063369,0.0001127775,0.9955621,0.000009927181,0.00002730924,0.002150446],"study_design_scores_gemma":[0.002016166,0.000223054,0.0005421792,0.000010726,0.000007334161,0.000008622784,0.00004585986,0.0009693631,0.994653,0.00007479493,0.001210058,0.0002387774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996864,0.001433276,0.0001203467,0.00003179075,0.0001424254,0.0002853904,0.00002379445,0.000006883773,0.001092158],"genre_scores_gemma":[0.9984498,0.0001031663,0.0000890709,0.0002777937,0.00008796671,0.00002830833,0.00001224883,0.0000320904,0.0009195481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911668,"threshold_uncertainty_score":0.8580972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00612509110160536,"score_gpt":0.2162518929092451,"score_spread":0.2101268018076398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}