{"id":"W2993025665","doi":"10.1039/c9nr08128c","title":"Membrane lipids destabilize short interfering ribonucleic acid (siRNA)/polyethylenimine nanoparticles","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Technology Futures; Compute Canada","keywords":"Polyethylenimine; Small interfering RNA; Membrane; Chemistry; Nanoparticle; RNA; Biophysics; Nanotechnology; Cell biology; Biochemistry; Materials science; Biology; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496913,0.000226145,0.0002278641,0.00005199379,0.00005773367,0.00004320002,0.0003339311,0.0001898314,0.0002748886],"category_scores_gemma":[0.00004379194,0.0002111988,0.0001472425,0.0001048638,0.0000802474,0.0000132647,0.0002202293,0.0001232135,0.0002626855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002080887,"about_ca_system_score_gemma":0.00004367224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001890051,"about_ca_topic_score_gemma":0.00006064277,"domain_scores_codex":[0.9986049,0.00004702464,0.000283084,0.0004984888,0.0001651106,0.0004014066],"domain_scores_gemma":[0.999166,0.00001291707,0.00004442795,0.0005708018,0.00008264848,0.0001231822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510007,0.0000723497,0.009205298,0.00002795642,0.0000372144,0.00000324825,0.00005876353,0.00002170279,0.98388,0.00001381336,0.0007849429,0.005743664],"study_design_scores_gemma":[0.0003744626,0.0005871367,0.001716926,0.00003641711,0.0000182147,0.0000205658,0.0001002029,0.00009090396,0.9771672,0.00001075964,0.01960217,0.0002749693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996164,0.000581223,0.0001758308,0.0001227352,0.0005794078,0.0002049491,0.00001294477,0.00003856448,0.00212032],"genre_scores_gemma":[0.9961107,0.0001667643,0.0004721391,0.0003068179,0.0002401949,0.00002216386,0.00004145887,0.00003860964,0.002601192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01881722,"threshold_uncertainty_score":0.8612436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102438204764488,"score_gpt":0.237586444241244,"score_spread":0.2265620621935991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}