{"id":"W2993025665","doi":"10.1039/c9nr08128c","title":"Membrane lipids destabilize short interfering ribonucleic acid (siRNA)/polyethylenimine nanoparticles","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Technology Futures; Compute Canada","keywords":"Polyethylenimine; Small interfering RNA; Membrane; Chemistry; Nanoparticle; RNA; Biophysics; Nanotechnology; Cell biology; Biochemistry; Materials science; Biology; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688573,0.0003669257,0.0002416197,0.0001284901,0.0001611496,0.0002751684,0.0001793446,0.0003942812,0.0005044523],"category_scores_gemma":[0.0002083246,0.000199977,0.0002429874,0.00006565476,0.0002127696,0.0002804796,0.0003315051,0.0003496665,0.0002888311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002890762,"about_ca_system_score_gemma":0.0001571111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000606854,"about_ca_topic_score_gemma":0.0006355307,"domain_scores_codex":[0.9998546,0.00002279692,0.00001359589,0.00003073792,0.00004948468,0.00002880948],"domain_scores_gemma":[0.999897,0.00002922999,0.00003255149,0.000006875838,0.00002031483,0.00001412589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001479735,0.000003661361,0.00004059374,0.00001364837,0.000002701091,0.0000227934,0.00001119856,0.0000673219,0.999527,0.00001610524,0.000005112184,0.0002750449],"study_design_scores_gemma":[0.000003330397,0.00004545293,0.0004736924,0.000002329244,0.000005412749,0.00004102743,0.000008551696,0.0005970115,0.9984451,0.00001330768,0.000362833,0.000002023623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994166,0.0008592968,0.003875805,0.00006726516,0.00001797226,0.00003031115,0.00004117762,0.00005800444,0.0008841543],"genre_scores_gemma":[0.9956007,0.0004667222,0.002546689,0.00007253579,0.000005797511,0.00003579595,0.00008490618,0.00002903636,0.001157722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000606854,"threshold_uncertainty_score":0.002097428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102438204764488,"score_gpt":0.237586444241244,"score_spread":0.2265620621935991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}