{"id":"W2993046104","doi":"10.1016/s1474-4422(19)30394-1","title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study","year":2019,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université Laval; Hôpital de l'Enfant-Jésus; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia","funders":"Janssen Pharmaceuticals; National Institute of Neurological Disorders and Stroke; National Institute on Aging; UCLH Biomedical Research Centre; National Health and Medical Research Council; Medical Research Council; GE Healthcare; Alzheimer's Disease Research Center, Emory University; Genentech; Centre Hospitalier Universitaire de Nîmes; Institut de France; Hjärnfonden; Demensfonden; H. Lundbeck A/S; Stockholm läns landsting; Centre Hospitalier Universitaire de Nice; Fédération pour la Recherche sur le Cerveau; Roche; Stockholms Läns Landsting; Biogen; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung; Guarantors of Brain; National Institute for Health and Care Research; Association France Parkinson; Stichting Dioraphte; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Astex Pharmaceuticals; Weston Brain Institute; Alzheimerfonden; Karolinska Institutet; ZonMw; National Institutes of Health; Alzheimer's Drug Discovery Foundation; TauRx Pharmaceuticals; UCB; Ministero della Salute; Assistance Publique - Hôpitaux de Paris; AbbVie; Fondation Brain Canada; Vetenskapsrådet; Cytokinetics; National Medical Research Council; Alzheimer Nederland; Instituto de Salud Carlos III; UK Dementia Research Institute; Ontario Brain Institute; Ministero dello Sviluppo Economico; Heart and Stroke Foundation of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Novartis; Fondation Roger de Spoelberch; Eli Lilly and Company; Amgen; Association for Frontotemporal Degeneration; Alexion Pharmaceuticals; Canadian Institutes of Health Research; Alzheimer's Society","keywords":"C9orf72; Frontotemporal dementia; Age of onset; Dementia; Retrospective cohort study; Medicine; Disease; Cohort; Internal medicine; Oncology; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001498812,0.001063244,0.0008672077,0.00193287,0.001132181,0.002002268,0.001297176,0.001752049,0.002369239],"category_scores_gemma":[0.003218333,0.001474969,0.002081312,0.00365007,0.0007840866,0.001939074,0.001232139,0.002067092,0.0005621784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007764528,"about_ca_system_score_gemma":0.0006549656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02220919,"about_ca_topic_score_gemma":0.01832233,"domain_scores_codex":[0.9990985,0.0001745773,0.0001234051,0.0003368797,0.00007795439,0.0001886614],"domain_scores_gemma":[0.9966124,0.0004260407,0.001413614,0.0006735992,0.0002905408,0.0005836992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006750952,0.00006249859,0.9972857,0.00001456609,0.0004574839,0.0003338926,0.0002134202,0.00003922608,0.000226997,0.00002990234,0.0001869327,0.0004743297],"study_design_scores_gemma":[0.00002711748,0.00008426436,0.9986804,0.00001066184,0.0001714875,0.0004572167,0.0002988506,0.00007276024,0.00002390108,0.00003025834,0.0001297297,0.00001332731],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997402,0.0006715034,0.00007889135,0.00006854394,0.00002169274,0.000007741382,0.001339801,0.000006112414,0.00040379],"genre_scores_gemma":[0.9976434,0.0004334862,0.00008795401,0.00006154114,0.00002994331,0.00001580072,0.001341705,0.000007875658,0.0003783391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02220919,"threshold_uncertainty_score":0.04415983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486820205777286,"score_gpt":0.3047817556544416,"score_spread":0.2799135535966688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}