{"id":"W2993046104","doi":"10.1016/s1474-4422(19)30394-1","title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study","year":2019,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université Laval; Hôpital de l'Enfant-Jésus; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia","funders":"Janssen Pharmaceuticals; National Institute of Neurological Disorders and Stroke; National Institute on Aging; UCLH Biomedical Research Centre; National Health and Medical Research Council; Medical Research Council; GE Healthcare; Alzheimer's Disease Research Center, Emory University; Genentech; Centre Hospitalier Universitaire de Nîmes; Institut de France; Hjärnfonden; Demensfonden; H. Lundbeck A/S; Stockholm läns landsting; Centre Hospitalier Universitaire de Nice; Fédération pour la Recherche sur le Cerveau; Roche; Stockholms Läns Landsting; Biogen; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung; Guarantors of Brain; National Institute for Health and Care Research; Association France Parkinson; Stichting Dioraphte; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Astex Pharmaceuticals; Weston Brain Institute; Alzheimerfonden; Karolinska Institutet; ZonMw; National Institutes of Health; Alzheimer's Drug Discovery Foundation; TauRx Pharmaceuticals; UCB; Ministero della Salute; Assistance Publique - Hôpitaux de Paris; AbbVie; Fondation Brain Canada; Vetenskapsrådet; Cytokinetics; National Medical Research Council; Alzheimer Nederland; Instituto de Salud Carlos III; UK Dementia Research Institute; Ontario Brain Institute; Ministero dello Sviluppo Economico; Heart and Stroke Foundation of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Novartis; Fondation Roger de Spoelberch; Eli Lilly and Company; Amgen; Association for Frontotemporal Degeneration; Alexion Pharmaceuticals; Canadian Institutes of Health Research; Alzheimer's Society","keywords":"C9orf72; Frontotemporal dementia; Age of onset; Dementia; Retrospective cohort study; Medicine; Disease; Cohort; Internal medicine; Oncology; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570513,0.00008411874,0.000225895,0.0000465434,0.00004154782,0.00001967217,0.000101399,0.00003723574,0.0001254985],"category_scores_gemma":[0.00005894468,0.00005772305,0.0000112246,0.00004038141,0.00006457679,0.00006828363,0.0001608521,0.0002011848,0.00001193369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004584745,"about_ca_system_score_gemma":0.00001942466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002368032,"about_ca_topic_score_gemma":0.0003970588,"domain_scores_codex":[0.9989319,0.0002321152,0.0001389509,0.0003081617,0.0002052192,0.0001836965],"domain_scores_gemma":[0.9995253,0.00003727736,0.00004026637,0.0002721874,0.00002571985,0.00009922839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001298535,0.00008911652,0.9976033,0.000005125768,0.00005267983,0.0001619658,0.0002091175,0.000006198274,0.0003948184,0.00004120774,0.00006810858,0.00006983451],"study_design_scores_gemma":[0.002026131,0.0007786307,0.994891,0.000004027673,0.00003591732,0.00003456292,0.00000722493,0.001778975,0.000001304076,0.0003389911,0.00005488514,0.00004831168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942355,0.0000685242,0.000002954971,0.00454049,0.00008689008,0.0008814064,0.00001008664,0.00001662366,0.0001575234],"genre_scores_gemma":[0.9985381,0.0001334444,0.00002241792,0.001008825,0.0001188948,0.00004009584,0.00002363819,0.00001059602,0.0001039608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004302626,"threshold_uncertainty_score":0.2353877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486820205777286,"score_gpt":0.3047817556544416,"score_spread":0.2799135535966688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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