{"id":"W2993062663","doi":"10.1172/jci131145","title":"Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; China Scholarship Council; Cancer Research Society; Wellcome Trust; McGill University","keywords":"Histone H4; Neurogenesis; Epigenetics; Neuroscience; Neocortex; Acetylation; Neural stem cell; Biology; Neurosphere; Rett syndrome; Cell biology; Genetics; Cellular differentiation; Stem cell; Gene; Adult stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008707641,0.0005157659,0.0001636565,0.0005228748,0.0002338714,0.0001627246,0.0001713907,0.0003502855,0.001608949],"category_scores_gemma":[0.0002966998,0.0001094069,0.0001674449,0.0003113128,0.0003826122,0.0001226355,0.0003567816,0.0002382898,0.0001622895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183703,"about_ca_system_score_gemma":0.0002583353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001225748,"about_ca_topic_score_gemma":0.001067063,"domain_scores_codex":[0.9999094,0.00001376034,0.00001297341,0.00002365756,0.00002344878,0.00001664057],"domain_scores_gemma":[0.9998895,0.00001618361,0.00006182392,0.000007045799,0.000009357938,0.00001599284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001696479,0.0001175661,0.2328358,0.0003983128,0.0003153228,0.03568611,0.0004887405,0.0007794191,0.6434571,0.002873889,0.001480088,0.07987117],"study_design_scores_gemma":[0.00007951306,0.0005358636,0.6957446,0.0001216346,0.0004790846,0.07892063,0.0005156819,0.001606008,0.1982925,0.003314207,0.0203526,0.00003770987],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914058,0.003552565,0.001483159,0.0002808687,0.00002102214,0.00001258912,0.000436191,0.0001013318,0.002706416],"genre_scores_gemma":[0.9971901,0.0010013,0.0006896646,0.0000359987,0.00001023895,0.000006788286,0.0001901946,0.000007815966,0.0008679312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608949,"threshold_uncertainty_score":0.005382419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04989035214837536,"score_gpt":0.3359547173995358,"score_spread":0.2860643652511604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}