{"id":"W2993083975","doi":"10.1016/s0140-6736(19)33041-7","title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":1213,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"AstraZeneca; Allergan; Gilead Sciences; Servier; Novartis Pharma; Newcastle University; Novo Nordisk; Abbott Laboratories; National Institute for Health and Care Research; Genentech; Arrowhead Pharmaceuticals; Coherus Biosciences; Intercept Pharmaceuticals; Alexion Pharmaceuticals; Medpace; GlaxoSmithKline; NGM Biopharmaceuticals; Birmingham Biomedical Research Centre; Pfizer; Celgene; Eli Lilly and Company; Bristol-Myers Squibb; Children's Liver Disease Foundation; Sanofi","keywords":"Obeticholic acid; Interim analysis; Medicine; Placebo; Steatohepatitis; Interim; Internal medicine; Fatty liver; Clinical trial; Disease; Alternative medicine; Political science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004782852,0.002460722,0.006120556,0.0005134274,0.0007417441,0.001805658,0.001025079,0.002656051,0.008478378],"category_scores_gemma":[0.004090911,0.0007523685,0.006949786,0.0006209195,0.001226513,0.001584023,0.0006963746,0.004223045,0.001327992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009389038,"about_ca_system_score_gemma":0.001372052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009281673,"about_ca_topic_score_gemma":0.002503497,"domain_scores_codex":[0.9977987,0.001320907,0.0001428515,0.000214901,0.0001330314,0.0003896229],"domain_scores_gemma":[0.997489,0.0009730239,0.0005355397,0.0003596764,0.0001937803,0.0004488899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9894801,0.0007447382,0.0002397598,0.0005873748,0.002164884,0.00003248558,0.00002903381,0.0002022069,0.000962302,0.00005382875,0.0005486973,0.004954572],"study_design_scores_gemma":[0.9747252,0.02073724,0.001823965,0.00005676906,0.001661284,0.00003020925,0.00001855124,0.0001648406,0.0001783971,0.0001986913,0.0003866939,0.00001813631],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462073,0.03071751,0.003736559,0.00244597,0.002412238,0.005324903,0.004181889,0.0004041137,0.00456935],"genre_scores_gemma":[0.9765678,0.005248389,0.003246032,0.002528321,0.0007372666,0.004758882,0.002535763,0.00008465661,0.004292869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008478378,"threshold_uncertainty_score":0.02836299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.034013412443777,"score_gpt":0.3386922773004405,"score_spread":0.3046788648566636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}