{"id":"W2993193401","doi":"10.1016/j.stemcr.2019.11.001","title":"Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme","year":2019,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Endoderm; Mesoderm; Biology; Induced pluripotent stem cell; Cell biology; Progenitor cell; Cellular differentiation; Ectoderm; Chondrogenesis; Stem cell; Directed differentiation; Embryonic stem cell; Embryo; Embryogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007655937,0.0003867679,0.0006454989,0.0001351606,0.0001092666,0.00005223983,0.0003119085,0.0004409174,0.00005415742],"category_scores_gemma":[0.00000997733,0.0003426288,0.0003635806,0.0002208048,0.00009592244,0.00001663102,0.0001828005,0.0002505662,0.00002663278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021123,"about_ca_system_score_gemma":0.0002239249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004273685,"about_ca_topic_score_gemma":0.000005854574,"domain_scores_codex":[0.9961087,0.0002315042,0.0013603,0.0009081897,0.0008217313,0.0005695738],"domain_scores_gemma":[0.9974704,0.00001343336,0.000696353,0.001179749,0.0004123122,0.0002277882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005486458,0.0001266318,0.00144964,0.001443694,0.000122668,0.00009667229,0.000121816,0.0002989836,0.9956691,0.00002632554,0.0005322979,0.00005731418],"study_design_scores_gemma":[0.0007665629,0.0003892702,0.0001071323,0.0002470269,0.00006825315,0.0003831172,0.0003141978,0.0003986511,0.9954084,0.00001985657,0.001526412,0.0003710932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916224,0.0007265001,0.0007261285,0.00002231456,0.0004817185,0.001419818,0.0000136931,0.00003487033,0.004952573],"genre_scores_gemma":[0.9885227,0.00003392696,0.001229291,0.00002368302,0.0001003692,0.00002935391,0.00005960487,0.00007237207,0.009928682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004976109,"threshold_uncertainty_score":0.9999025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251299811267773,"score_gpt":0.2701856410730082,"score_spread":0.2450556599462309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}