{"id":"W2993193401","doi":"10.1016/j.stemcr.2019.11.001","title":"Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme","year":2019,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Endoderm; Mesoderm; Biology; Induced pluripotent stem cell; Cell biology; Progenitor cell; Cellular differentiation; Ectoderm; Chondrogenesis; Stem cell; Directed differentiation; Embryonic stem cell; Embryo; Embryogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203358,0.000348094,0.0002019705,0.0002702923,0.0001679768,0.000273971,0.0002007799,0.0001975531,0.0007379365],"category_scores_gemma":[0.0001584083,0.0001923907,0.0002407758,0.0002116725,0.0002352345,0.0001375598,0.0002363327,0.0005099186,0.000492375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638283,"about_ca_system_score_gemma":0.0004735444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004312344,"about_ca_topic_score_gemma":0.001233458,"domain_scores_codex":[0.9998236,0.00002887645,0.00003074501,0.00004189308,0.00005149399,0.00002340367],"domain_scores_gemma":[0.9998873,0.00002032522,0.00003851649,0.00002247123,0.00001996028,0.00001142833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007998751,0.000003972938,0.00003144074,0.00001213979,8.688918e-7,0.000009769927,0.000004668336,0.00008898212,0.9990392,0.0001365942,0.00001591134,0.0006485662],"study_design_scores_gemma":[0.000003971884,0.00003077654,0.0003427849,0.000002313931,0.000004614432,0.00002831812,0.000004939141,0.0005988397,0.9967285,0.00002647932,0.002226049,0.000002455469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7399282,0.002112472,0.2432185,0.0003187804,0.0001668957,0.00120914,0.004039603,0.001240303,0.007766055],"genre_scores_gemma":[0.8357064,0.002023238,0.1497534,0.0001597154,0.00003311647,0.0008385815,0.003570987,0.0002259124,0.007688805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007379365,"threshold_uncertainty_score":0.002468646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251299811267773,"score_gpt":0.2701856410730082,"score_spread":0.2450556599462309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}