{"id":"W2993318304","doi":"10.1093/ecco-jcc/jjz194","title":"Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Mitacs","keywords":"Unfolded protein response; TLR5; Endoplasmic reticulum; Cytokine; Medicine; Cell biology; Thapsigargin; CD80; Immunology; Inflammatory bowel disease; Inflammation; CD86; Innate immune system; Toll-like receptor; Immune system; Biology; Internal medicine; T cell; CD40; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325146,0.0004654959,0.0004766896,0.0003912286,0.0002271785,0.0004492726,0.0001025647,0.0003682096,0.002157044],"category_scores_gemma":[0.0002673712,0.0001582828,0.0003067138,0.0002892185,0.0002414438,0.0002584323,0.0003979182,0.0005766557,0.0006156778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626069,"about_ca_system_score_gemma":0.00008462427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001131109,"about_ca_topic_score_gemma":0.0001963644,"domain_scores_codex":[0.999824,0.00002336753,0.00003068058,0.00005778358,0.00002917436,0.00003503161],"domain_scores_gemma":[0.9997646,0.0000307283,0.00008983376,0.00002811839,0.00002886285,0.00005786303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002610759,0.0001065891,0.02453471,0.0002809778,0.00003157535,0.002454396,0.0001993149,0.00003222189,0.9653005,0.00003881331,0.0001179344,0.00429227],"study_design_scores_gemma":[0.0002829614,0.003728186,0.6200919,0.0001058391,0.0002349403,0.0387726,0.001789641,0.0004127095,0.3278371,0.0002201445,0.006479314,0.00004468722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982005,0.0009148739,0.0003020399,0.00004352197,0.00001289948,0.00001478095,0.0002142795,0.0000156879,0.0002814052],"genre_scores_gemma":[0.9970716,0.000736309,0.0006686234,0.00007177371,0.00001795972,0.00002344942,0.0009120861,0.00001011877,0.0004880381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157044,"threshold_uncertainty_score":0.007215977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003415555337222315,"score_gpt":0.1958582655460663,"score_spread":0.192442710208844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}