{"id":"W2993489868","doi":"10.1186/s13148-019-0766-2","title":"The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care","year":2019,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Brain Tumour Charity","keywords":"Brain tumor; Medicine; Medical diagnosis; Neurology; Central nervous system; Human genetics; Oncology; Patient care; Internal medicine; Bioinformatics; Intensive care medicine; Pathology; Biology; Psychiatry; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003408215,0.0002280013,0.0002586616,0.0008322519,0.000608078,0.001305232,0.0006696641,0.0004531563,0.001818706],"category_scores_gemma":[0.01316097,0.0001109511,0.0002019432,0.0005936773,0.0004354554,0.0006391064,0.001091481,0.000552017,0.0006288886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001207106,"about_ca_system_score_gemma":0.001891083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002609838,"about_ca_topic_score_gemma":0.006662557,"domain_scores_codex":[0.9976643,0.0007893659,0.0002638516,0.0003480082,0.0007807196,0.000153768],"domain_scores_gemma":[0.9937751,0.001681779,0.00225466,0.0002862311,0.001251698,0.0007504115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001560792,0.0001493137,0.7948357,0.0001015953,0.00005575262,0.001095787,0.001047728,0.001084461,0.005511378,0.0001923943,0.003637631,0.1921322],"study_design_scores_gemma":[0.00003039807,0.0009137555,0.9308512,0.0003615659,0.0001813877,0.01320211,0.004169344,0.01624938,0.01553105,0.001307687,0.01712902,0.00007313918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836488,0.001145155,0.004898099,0.004402657,0.00008476136,0.00009885104,0.0002178793,0.0002131309,0.005290664],"genre_scores_gemma":[0.9891363,0.0004268433,0.009428786,0.0003902246,0.00004606372,0.00002192656,0.0001125592,0.0000285888,0.0004086191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003408215,"threshold_uncertainty_score":0.01802456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788344725762592,"score_gpt":0.3600271935792914,"score_spread":0.3221437463216655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}