{"id":"W2993545890","doi":"10.1158/1535-7163.targ-19-c027","title":"Abstract C027: A Phase I, dose finding study of BI 754111, an anti-LAG-3 antibody, in combination with BI 754091, an anti-PD-1 antibody, in patients with advanced solid tumors: preliminary results from the microsatellite stable (MSS) metastatic colorectal cancer (mCRC) cohort","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); University of Alberta","funders":"","keywords":"Blockade; Medicine; Antibody; Monoclonal antibody; Immune checkpoint; Lung cancer; Cancer; Cancer research; Internal medicine; T cell; Oncology; Immune system; Pharmacology; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001306639,0.002216491,0.001903219,0.0007213047,0.0006540075,0.001262573,0.001205031,0.001558374,0.003721077],"category_scores_gemma":[0.0006953199,0.0006206293,0.001064349,0.0005373975,0.00103377,0.0006632345,0.0003920672,0.004182502,0.001291979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001604199,"about_ca_system_score_gemma":0.003737092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004586643,"about_ca_topic_score_gemma":0.00917504,"domain_scores_codex":[0.9995167,0.0001739053,0.00002174462,0.00008720832,0.00006728559,0.0001331626],"domain_scores_gemma":[0.9991278,0.00009858971,0.00009242059,0.00005429356,0.00006588262,0.0005610756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5366206,0.1759382,0.009070463,0.0009938994,0.001574165,0.0006680384,0.0006037705,0.005069822,0.1414571,0.0005411246,0.0152232,0.1122396],"study_design_scores_gemma":[0.4030012,0.5655014,0.01394908,0.00003527448,0.0005084408,0.000418903,0.00008224464,0.001731615,0.01066584,0.0001475551,0.003904565,0.00005393324],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913629,0.001042964,0.0005240901,0.0005295834,0.00008304098,0.002547007,0.00166918,0.0001336593,0.002107529],"genre_scores_gemma":[0.9802393,0.001234312,0.003314032,0.001457264,0.0001642199,0.003432527,0.005736142,0.00005963753,0.004362501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004586643,"threshold_uncertainty_score":0.01244825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862583428759236,"score_gpt":0.3292702647812341,"score_spread":0.3106444304936418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}