{"id":"W2993605366","doi":"","title":"miRNA-34a down-regulates the triggering receptor and phagocytosis sensor TREM2 in age-related macular degeneration (AMD)","year":2015,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Macular degeneration; Phagocytosis; TREM2; microRNA; Medicine; Receptor; Ophthalmology; Biology; Immunology; Internal medicine; Gene; Genetics; Myeloid cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003225669,0.0002838552,0.0005074324,0.0003477088,0.0002798103,0.0004391778,0.0002545687,0.0005192073,0.001878465],"category_scores_gemma":[0.0004577959,0.0003030497,0.0005302805,0.0001561356,0.0002924326,0.000245394,0.000345909,0.0008315655,0.000641831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689732,"about_ca_system_score_gemma":0.0003697712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005896889,"about_ca_topic_score_gemma":0.0006238323,"domain_scores_codex":[0.9996548,0.00005352118,0.00004182453,0.00007666123,0.00009751352,0.00007576868],"domain_scores_gemma":[0.9998446,0.00002261596,0.00005243065,0.00001410315,0.00003302304,0.0000332927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002206358,0.0001527215,0.002540354,0.0002355146,0.00008996059,0.0003796114,0.00005787921,0.0001731247,0.9842809,0.0004086705,0.0007889403,0.008685899],"study_design_scores_gemma":[0.0005023555,0.001928853,0.06875129,0.00005298203,0.0005228363,0.002907398,0.0002045217,0.005027864,0.9033287,0.00095627,0.01576485,0.00005213073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890126,0.004762337,0.00254843,0.0003983471,0.0002785133,0.00004312285,0.0006668564,0.0002589388,0.00203092],"genre_scores_gemma":[0.9950619,0.000969268,0.001427888,0.0001906437,0.00003478634,0.00004760782,0.0003459476,0.00003334031,0.00188858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878465,"threshold_uncertainty_score":0.006284118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04471907224027388,"score_gpt":0.2916330224462979,"score_spread":0.246913950206024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}