{"id":"W2993613795","doi":"10.1038/s41380-019-0605-z","title":"Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group","year":2019,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; European Commission; Universiteit Utrecht; Biotechnology and Biological Sciences Research Council; ZonMw; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; Division of Materials Research; King's College London; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; South London and Maudsley NHS Foundation Trust; Heart and Stroke Foundation of Canada","keywords":"DNA methylation; Epigenetics; Biology; Epigenome; Genetics; Methylation; Epigenomics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005141282,0.001120198,0.002067744,0.001773615,0.0006395037,0.001702851,0.0009612999,0.000867728,0.002716971],"category_scores_gemma":[0.009407878,0.0004787657,0.007610859,0.003710486,0.0004798698,0.0006776894,0.001404996,0.00127351,0.0002269984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004851239,"about_ca_system_score_gemma":0.0007545081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007910034,"about_ca_topic_score_gemma":0.009409527,"domain_scores_codex":[0.996815,0.001299122,0.000276256,0.001145635,0.0002503837,0.0002136144],"domain_scores_gemma":[0.995323,0.002610595,0.0006267561,0.0009235247,0.0002950445,0.0002210479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002697726,0.00004239091,0.5820819,0.004029124,0.3464524,0.0006716913,0.0003818594,0.002979349,0.005434441,0.00144281,0.004545751,0.04924057],"study_design_scores_gemma":[0.0002886009,0.0002927521,0.7435057,0.0008747796,0.2306134,0.000915809,0.0003044296,0.004152701,0.00241699,0.005200082,0.01136305,0.00007168992],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6063405,0.334296,0.03300586,0.005395575,0.0006006497,0.0001156068,0.01610685,0.0005372851,0.003601724],"genre_scores_gemma":[0.9735251,0.0188692,0.003114007,0.000602045,0.0001751369,0.00008200826,0.002973074,0.0001129968,0.0005463848],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007910034,"threshold_uncertainty_score":0.02719003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045159606813852,"score_gpt":0.2902895620466499,"score_spread":0.2498379659785113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}