{"id":"W2993613817","doi":"10.1158/1535-7163.targ-19-c048","title":"Abstract C048: Novel master checkpoint Cbl-b siRNA-based adoptive cellular therapy: Superior antitumor efficacy in a syngeneic murine hepatocellular carcinoma Hepa1-6 model following APN401 monotherapy and synergistic effects with anti-PD1","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cancer research; In vivo; Immune system; Immunotherapy; Medicine; Hepatocellular carcinoma; Cancer; Immunology; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734123,0.0005380456,0.0003852592,0.0003512706,0.0001570047,0.0002333347,0.000295129,0.0003949367,0.0020468],"category_scores_gemma":[0.00005210841,0.0001112249,0.0002336925,0.0001599954,0.0002418871,0.0002306136,0.0001102319,0.000916732,0.0005278778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004157813,"about_ca_system_score_gemma":0.0003982953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009769097,"about_ca_topic_score_gemma":0.001276347,"domain_scores_codex":[0.9998907,0.00001285007,0.000009386506,0.0000237838,0.00003748978,0.00002575736],"domain_scores_gemma":[0.9999472,0.000004440444,0.00001225335,0.000006796132,0.000008779914,0.00002052168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005766305,0.0002614165,0.00006152916,0.00007053647,0.000008194795,0.00003684224,0.00001118269,0.0001057597,0.9949867,0.0001037216,0.0003125215,0.003465065],"study_design_scores_gemma":[0.0001171012,0.001640662,0.0007566236,0.000004534854,0.00002339465,0.0001534259,0.000009373943,0.0006535978,0.9944564,0.00002252319,0.002158033,0.000004350077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886881,0.001943508,0.004182242,0.0003090624,0.0001356714,0.0001492886,0.0009844977,0.0003727547,0.003234959],"genre_scores_gemma":[0.9877973,0.0009551573,0.00374554,0.00009283213,0.00002335388,0.0001786252,0.001023323,0.00002966346,0.006154219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0020468,"threshold_uncertainty_score":0.006847203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431595127598826,"score_gpt":0.280333360489796,"score_spread":0.2460174092138077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}