{"id":"W2993637233","doi":"10.1002/ajh.25701","title":"The road to biosimilars in rare diseases ‐ ongoing lessons from Gaucher disease","year":2019,"lang":"en","type":"review","venue":"American Journal of Hematology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Allergan; Sanofi Genzyme; Sanofi; Pfizer; Amgen","keywords":"Biosimilar; Medicine; European union; Comparability; Orphan drug; Business; International trade; Bioinformatics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05026233,0.000853527,0.001931512,0.002631516,0.001930825,0.01002596,0.002779196,0.0156128,0.01306997],"category_scores_gemma":[0.07991897,0.0006583337,0.00142641,0.002274351,0.01071147,0.01948281,0.005357952,0.02349569,0.004059754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00512688,"about_ca_system_score_gemma":0.008567544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002012874,"about_ca_topic_score_gemma":0.00292997,"domain_scores_codex":[0.9812307,0.00803681,0.001836507,0.001424203,0.006512685,0.0009591464],"domain_scores_gemma":[0.9185031,0.05533077,0.003025375,0.002776122,0.01225926,0.008105374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005296702,0.0002717169,0.0006699403,0.002591854,0.00008963248,0.0009821185,0.001109778,0.0008735493,0.0009070448,0.1834042,0.3275466,0.4810239],"study_design_scores_gemma":[0.0001740894,0.0003914854,0.00055064,0.004094849,0.00003344459,0.001256559,0.0007604723,0.0003445055,0.0004633923,0.1483615,0.843502,0.00006705066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.001439627,0.3594714,0.003352786,0.6167794,0.01165998,0.00003253154,0.0001097657,0.0001719973,0.006982473],"genre_scores_gemma":[0.04051958,0.566833,0.0111726,0.3310715,0.04471959,0.0001137341,0.0002510737,0.0002114996,0.00510735],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.05026233,"threshold_uncertainty_score":0.2658158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.047903286074954,"score_gpt":0.3767017784107156,"score_spread":0.3287984923357616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}