{"id":"W2993751725","doi":"10.1016/j.jtho.2019.11.023","title":"Evolution and Clinical Impact of EGFR Mutations in Circulating Free DNA in the BELIEF Trial","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Merck Sharp and Dohme; EMD Serono; Daiichi-Sankyo; Clovis Oncology; Sanofi; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Genentech; Seattle Genetics; Merck KGaA; Regeneron Pharmaceuticals; Institute of Cancer Research; F. Hoffmann-La Roche; Takeda Pharmaceutical Company; AbbVie; Roche; Celgene; Novartis; Amgen; Boehringer Ingelheim; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Bayer; Illumina; Merck; Eli Lilly and Company; Samsung; Bristol-Myers Squibb; AstraZeneca; Pfizer","keywords":"Medicine; Clinical trial; DNA; Oncology; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004631613,0.0002739525,0.001014256,0.0002596868,0.000305524,0.001275685,0.0004330185,0.0009047445,0.003566084],"category_scores_gemma":[0.02122672,0.0001559389,0.0006753503,0.0004981096,0.0005578981,0.002308435,0.000535767,0.002217277,0.0003706326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007074205,"about_ca_system_score_gemma":0.0006790694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006280215,"about_ca_topic_score_gemma":0.0008644192,"domain_scores_codex":[0.9982219,0.0008890149,0.0001026772,0.0002842555,0.0002114784,0.0002906164],"domain_scores_gemma":[0.9890773,0.007017786,0.001564257,0.0007145421,0.0004365995,0.001189461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4190071,0.002477124,0.3212888,0.0004476195,0.002680957,0.0005511232,0.000430914,0.006985439,0.01064816,0.003229301,0.00486519,0.2273883],"study_design_scores_gemma":[0.02607222,0.1199298,0.7885634,0.0002934322,0.005894862,0.002454763,0.0007231078,0.01886113,0.008338703,0.01528846,0.01338309,0.0001971014],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939532,0.002201229,0.0003422615,0.0008410038,0.00005531706,0.00002576499,0.0006227365,0.00002154448,0.001936983],"genre_scores_gemma":[0.9981993,0.0002429612,0.0001274339,0.0002787153,0.00004256965,0.00001915919,0.0004923429,0.000008984666,0.000588419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004631613,"threshold_uncertainty_score":0.02449459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03973765988084979,"score_gpt":0.5141260334831764,"score_spread":0.4743883736023267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}