{"id":"W2993772312","doi":"","title":"Pigment Dispersion Syndrome and Pigmentary Glaucoma Associated Variants in Premelanosome Protein (PMEL) Cause Protein Processing and Fibrillogenesis Defects","year":2018,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"","keywords":"Fibrillogenesis; Glaucoma; Ophthalmology; Medicine; Genetics; Biology; Fibril","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002846441,0.001563734,0.0003468458,0.001266646,0.0006476538,0.0004849288,0.0005164497,0.001641635,0.004510276],"category_scores_gemma":[0.001214397,0.0002822762,0.00060646,0.0006970526,0.0007741418,0.0004065585,0.0007210968,0.0008013868,0.0007077941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229771,"about_ca_system_score_gemma":0.0002183449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007594295,"about_ca_topic_score_gemma":0.0009761373,"domain_scores_codex":[0.999598,0.00007551075,0.00006658477,0.0001081433,0.000103073,0.00004868807],"domain_scores_gemma":[0.9989493,0.00038262,0.0003970888,0.00007107334,0.00005156636,0.0001483131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002819501,0.000386817,0.06452382,0.0002196888,0.0004423347,0.2750543,0.001009217,0.0009220402,0.6296179,0.004322899,0.002048435,0.01863308],"study_design_scores_gemma":[0.000557767,0.0008404431,0.2990105,0.0001614607,0.0006180048,0.4719581,0.0007444429,0.005226411,0.2027392,0.005418828,0.01260471,0.0001201576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939681,0.0007201819,0.002252294,0.0003603204,0.0001115036,0.00003111175,0.0004815147,0.0001034828,0.001971399],"genre_scores_gemma":[0.9963107,0.0001578568,0.001780087,0.0001091093,0.00004879661,0.00001350971,0.0002427921,0.00004038123,0.001296783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004510276,"threshold_uncertainty_score":0.01508838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047215789461868,"score_gpt":0.2955634624252768,"score_spread":0.2750913045306581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}