{"id":"W2994033895","doi":"10.1530/erc-19-0420","title":"The epigenetic and transcriptional landscape of neuroendocrine prostate cancer","year":2019,"lang":"en","type":"review","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Medical Research Council; Prostate Cancer Foundation","keywords":"Epigenetics; Reprogramming; Biology; Prostate cancer; Epigenome; Lineage (genetic); Cancer research; DNA methylation; Phenotype; Cancer; Transcription factor; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294052,0.0004190661,0.0006290324,0.0008983343,0.0002020839,0.0006423689,0.0003716062,0.0005590117,0.002873729],"category_scores_gemma":[0.000280997,0.0001327052,0.0002256966,0.0008767199,0.0002944031,0.0006398597,0.0005146972,0.001067672,0.001375093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004308228,"about_ca_system_score_gemma":0.0007255631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008921964,"about_ca_topic_score_gemma":0.002301295,"domain_scores_codex":[0.9999254,0.00001322552,0.000009298057,0.00001382484,0.0000292258,0.000009029156],"domain_scores_gemma":[0.999902,0.00003951655,0.00001460762,0.00000349737,0.00002809775,0.00001212695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004711613,0.00002972325,0.0002677982,0.01069504,0.00006498952,0.0002397862,0.00009235772,0.0003584836,0.004994152,0.005348972,0.02972764,0.948134],"study_design_scores_gemma":[0.000004030733,0.00003977224,0.0007782587,0.001222753,0.00004089469,0.0009966034,0.00004287791,0.00005493334,0.0006088058,0.001664438,0.9945372,0.00000944153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002104155,0.9975954,0.0001438326,0.0004048513,0.0001826457,0.000002640289,0.00002884608,0.000008912752,0.001422502],"genre_scores_gemma":[0.00104168,0.9976109,0.0001029964,0.0002096266,0.0001377685,0.000003169297,0.00003683631,0.000001330988,0.0008555559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002873729,"threshold_uncertainty_score":0.009613574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0435413120398401,"score_gpt":0.3749267514232253,"score_spread":0.3313854393833853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}