{"id":"W2994040423","doi":"10.1085/jgp.201912397","title":"The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate","year":2019,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Compute Canada","keywords":"Gating; Biophysics; Chemistry; Ion channel; KcsA potassium channel; Hydrophobic effect; Crystallography; Chemical physics; Static electricity; Conformational change; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006762442,0.0002841674,0.0002885165,0.0000664674,0.0002606967,0.000284605,0.0002648081,0.0002852159,0.00265417],"category_scores_gemma":[0.0001905695,0.0001741102,0.0003023752,0.00005622104,0.0003385819,0.0004586258,0.0005082592,0.000505174,0.0006232273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011687,"about_ca_system_score_gemma":0.0002905074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006375612,"about_ca_topic_score_gemma":0.0005159729,"domain_scores_codex":[0.9999498,0.000004752352,0.00000281341,0.000009562587,0.00001365867,0.00001933771],"domain_scores_gemma":[0.9999205,0.00001387155,0.00002176326,0.000006808736,0.000009966448,0.0000270017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004388787,0.00006370552,0.0009050588,0.00010187,0.0000288866,0.000311906,0.00007462364,0.004652898,0.9895102,0.001629712,0.0002093518,0.002072873],"study_design_scores_gemma":[0.0004399118,0.001160696,0.02072236,0.00005506588,0.0001031829,0.001242644,0.0003651554,0.0789274,0.8819491,0.003740228,0.01118199,0.0001123005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916072,0.000196128,0.005617577,0.0001018799,0.00002908879,0.00002783953,0.00007996424,0.0001194939,0.00222093],"genre_scores_gemma":[0.9977918,0.0001340996,0.00127769,0.00004143344,0.0000051867,0.00001318882,0.0001058887,0.00001738448,0.0006133094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265417,"threshold_uncertainty_score":0.008879066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122631466652737,"score_gpt":0.2561585301566019,"score_spread":0.2349322154900746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}