{"id":"W2994130923","doi":"10.1002/ejhf.1674","title":"The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties: A Translational Approach","year":2019,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"European Commission; National Institute for Health and Care Research","keywords":"Medicine; Heart failure; Cathepsin; Cathepsin D; Cathepsin S; Cathepsin B; Internal medicine; Hazard ratio; Endocrinology; Cathepsin K; Cathepsin L; Autophagy; Confidence interval; Apoptosis; Biology; Biochemistry; Enzyme; Osteoclast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008497524,0.0001102034,0.0001938708,0.00004005626,0.00005906705,0.00001438188,0.0002339152,0.00005363502,0.000006108147],"category_scores_gemma":[0.00003638942,0.00006229519,0.000128435,0.00006600388,0.0000600471,0.00001108055,0.00004491308,0.0001990099,0.000002511611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002367997,"about_ca_system_score_gemma":0.00008630155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002757023,"about_ca_topic_score_gemma":0.000004444898,"domain_scores_codex":[0.9986296,0.0005016726,0.0003911626,0.0001360547,0.0001940753,0.0001474925],"domain_scores_gemma":[0.9994563,0.00001590793,0.0001868333,0.0001716486,0.0001351045,0.00003414955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001965517,0.00006855852,0.0002524638,0.00002352082,0.00002441843,0.000001739984,0.0002972314,0.0001172509,0.9979271,0.0001954611,0.0005861603,0.0003095326],"study_design_scores_gemma":[0.00176583,0.002565325,0.002728949,0.0001571938,0.00004310061,0.0003392184,0.002141471,0.0002135848,0.8652613,0.0005426069,0.1240022,0.0002393035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938384,0.00358397,0.00006836517,0.00211579,0.00005370228,0.0002303695,0.00001062578,0.000001173293,0.00009763308],"genre_scores_gemma":[0.9978451,0.00004860283,0.001740145,0.0001251197,0.0002023165,0.000001628924,0.000005415576,0.00001482714,0.00001684285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326659,"threshold_uncertainty_score":0.2540324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00586983924847337,"score_gpt":0.1878023433499378,"score_spread":0.1819325041014645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}