{"id":"W2994185727","doi":"10.3389/fnins.2019.01281","title":"Pituitary Adenylate Cyclase-Activating Peptide (PACAP)-Glutamate Co-transmission Drives Circadian Phase-Advancing Responses to Intrinsically Photosensitive Retinal Ganglion Cell Projections by Suprachiasmatic Nucleus","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; University of Illinois at Urbana-Champaign; National Institutes of Health; Canadian Institutes of Health Research; Bispebjerg Hospital","keywords":"Suprachiasmatic nucleus; Neuroscience; Circadian rhythm; Retinal ganglion cell; Glutamate receptor; Nucleus; Adenylate kinase; Chemistry; Biology; Internal medicine; Endocrinology; Cell biology; Retina; Receptor; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332246,0.0004006175,0.0002820392,0.0003469151,0.000189332,0.0003972472,0.0004288296,0.0002500816,0.001223171],"category_scores_gemma":[0.0002016822,0.0002798964,0.0002872506,0.0001549682,0.0006246581,0.00028982,0.000426356,0.001196805,0.0004252545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007023123,"about_ca_system_score_gemma":0.0005230107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001918273,"about_ca_topic_score_gemma":0.004286684,"domain_scores_codex":[0.9996676,0.00003024407,0.00003053108,0.00008282327,0.0001190477,0.00006971818],"domain_scores_gemma":[0.9995789,0.00004749178,0.0001426513,0.00004345209,0.00002819347,0.0001592864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005694117,0.000007618768,0.00009561633,0.000008322399,0.00000141146,0.00003312018,0.0000090126,0.000014588,0.999429,0.00005135619,0.00001178572,0.0002811513],"study_design_scores_gemma":[0.00003295212,0.0002421499,0.01233466,0.000006974231,0.00001542842,0.0002198358,0.00005137812,0.001131462,0.9849311,0.00007477782,0.0009525725,0.000006755275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996345,0.0004395886,0.001695038,0.0001020166,0.00004087252,0.00001325579,0.0002393825,0.00008817492,0.001036625],"genre_scores_gemma":[0.9936343,0.0003985916,0.001879294,0.00006130154,0.00001985026,0.00003350579,0.0004208636,0.00007372705,0.003478422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918273,"threshold_uncertainty_score":0.005095601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125282366868504,"score_gpt":0.2635829026601972,"score_spread":0.2523300789915122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}