{"id":"W2994263977","doi":"10.1074/jbc.ra119.011363","title":"Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of (R)-1,3-butanediol","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Ontario Research Foundation; Genome Canada","keywords":"Deoxyribose; 2,3-Butanediol; Biosynthesis; Chemistry; Biochemistry; 1,4-Butanediol; Stereochemistry; Enzyme; Fermentation; Nucleic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616292,0.0005340312,0.0004451881,0.0002881121,0.0001160275,0.000547922,0.0003582155,0.0002650607,0.0004302494],"category_scores_gemma":[0.0002511825,0.0002237438,0.0004337718,0.0005043824,0.0001856568,0.000256002,0.0003196875,0.0004932762,0.0003095711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093924,"about_ca_system_score_gemma":0.0004191835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374832,"about_ca_topic_score_gemma":0.002001424,"domain_scores_codex":[0.9997777,0.00004730724,0.00002923347,0.00003680804,0.00006055861,0.00004838132],"domain_scores_gemma":[0.9999127,0.00001451417,0.00002615053,0.000007986802,0.00001519925,0.00002340296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566103,0.0001062832,0.0004127552,0.00006769461,0.00001619249,0.0001703775,0.00003051351,0.002568807,0.9917818,0.0003639912,0.00004332442,0.004281482],"study_design_scores_gemma":[0.00004882191,0.0004957621,0.001728129,0.00001371003,0.00004409187,0.0002421205,0.00008701538,0.01037156,0.9815591,0.0001456314,0.005247384,0.00001670907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829985,0.001134408,0.01325229,0.0001027069,0.00003095331,0.0001283486,0.0004188514,0.00009033517,0.001843601],"genre_scores_gemma":[0.9711746,0.001240345,0.02481961,0.00003088422,0.000006678646,0.0000481549,0.000764775,0.0000559939,0.001858914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374832,"threshold_uncertainty_score":0.003695965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009242340950478828,"score_gpt":0.2115338054762805,"score_spread":0.2022914645258017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}