{"id":"W2994334473","doi":"10.1158/1535-7163.targ-19-c077","title":"Abstract C077: Updated results of phase 1 study of ripretinib (DCC-2618), a broad-spectrum KIT and PDGFRA inhibitor, in patients with gastrointestinal stromal tumor (GIST) by line of therapy (NCT02571036)","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research","funders":"","keywords":"GiST; Medicine; PDGFRA; Response Evaluation Criteria in Solid Tumors; Internal medicine; Trabectedin; Phases of clinical research; Dosing; Gastroenterology; Oncology; Surgery; Pharmacology; Stromal cell; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006753144,0.001117089,0.002107947,0.00101845,0.0005917873,0.002290898,0.001654532,0.001384581,0.007556058],"category_scores_gemma":[0.006116201,0.0004892162,0.001848735,0.001425001,0.0003483476,0.001092,0.0006743827,0.002589297,0.002800854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001889342,"about_ca_system_score_gemma":0.004158808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003937144,"about_ca_topic_score_gemma":0.0102804,"domain_scores_codex":[0.997182,0.0009399949,0.0002343323,0.0003406935,0.001020105,0.0002830063],"domain_scores_gemma":[0.9933456,0.001129952,0.001483794,0.000590075,0.002438795,0.001011816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1448104,0.007107811,0.05459705,0.005731513,0.009962389,0.001014624,0.000379139,0.005692797,0.04980419,0.0008837056,0.3417662,0.3782502],"study_design_scores_gemma":[0.1683187,0.1071291,0.2749822,0.001339881,0.01836425,0.005884019,0.0002335485,0.004453188,0.02957666,0.001625755,0.3876716,0.0004211132],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.520816,0.03664875,0.005184805,0.007645211,0.001693147,0.01025788,0.3642145,0.001474738,0.05206506],"genre_scores_gemma":[0.481538,0.01277639,0.01349163,0.0119553,0.001309565,0.00501774,0.4596127,0.000742922,0.01355579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007556058,"threshold_uncertainty_score":0.03571451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661905398869492,"score_gpt":0.3009924335799647,"score_spread":0.2843733795912698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}