{"id":"W2994334473","doi":"10.1158/1535-7163.targ-19-c077","title":"Abstract C077: Updated results of phase 1 study of ripretinib (DCC-2618), a broad-spectrum KIT and PDGFRA inhibitor, in patients with gastrointestinal stromal tumor (GIST) by line of therapy (NCT02571036)","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research","funders":"","keywords":"GiST; Medicine; PDGFRA; Response Evaluation Criteria in Solid Tumors; Internal medicine; Trabectedin; Phases of clinical research; Dosing; Gastroenterology; Oncology; Surgery; Pharmacology; Stromal cell; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002061762,0.0003223894,0.0006851639,0.0001928865,0.00001974727,0.00001044455,0.0001472372,0.00003362044,0.00005884763],"category_scores_gemma":[0.00002111005,0.0002460563,0.00007687764,0.0003478811,0.0001833367,0.00005299958,0.00004887437,0.0003210463,0.000001112537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009544064,"about_ca_system_score_gemma":0.0002478144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009259935,"about_ca_topic_score_gemma":0.00006658252,"domain_scores_codex":[0.9975628,0.00009970173,0.0007279337,0.0004373866,0.0007558026,0.0004163623],"domain_scores_gemma":[0.9985117,0.00005851673,0.0004650737,0.0004802512,0.0003261641,0.0001583192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03890174,0.01312525,0.7151645,0.0001800586,0.0005461427,0.0002144741,0.000485857,0.00007692939,0.2290287,0.000005408225,0.00002135549,0.002249617],"study_design_scores_gemma":[0.1173144,0.09068783,0.548387,0.00135331,0.0002691714,0.0000576019,0.0006667622,0.0003311041,0.2405158,0.00002039294,0.00007447653,0.0003222399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970728,0.0005543153,0.00003315396,0.0001333249,0.00001966111,0.001789781,0.0003032702,0.00001516588,0.00007853199],"genre_scores_gemma":[0.999204,0.00003314077,0.0004716878,0.00005126362,0.00001197583,0.00003114463,0.0001218799,0.00004852273,0.00002635283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1667775,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661905398869492,"score_gpt":0.3009924335799647,"score_spread":0.2843733795912698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}