{"id":"W2994585786","doi":"10.3389/fonc.2019.01302","title":"Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics","year":2019,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Iran National Science Foundation; Iran's National Elites Foundation; Iran University of Medical Sciences","keywords":"Spheroid; Telomerase; Stem cell; Renal stem cell; Cancer research; Renal carcinoma; Adenocarcinoma; Biology; Medicine; Pathology; Oncology; Internal medicine; Cell biology; Renal cell carcinoma; Cell culture; Cancer; Progenitor cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204074,0.0001706613,0.0004015491,0.0002765209,0.0002307589,0.0002673609,0.00008378269,0.0001895205,0.001646853],"category_scores_gemma":[0.0001659204,0.0000853526,0.0002802126,0.0002786979,0.0001151063,0.0001810241,0.0001420613,0.0002797582,0.0006149492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119852,"about_ca_system_score_gemma":0.0003325935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00180138,"about_ca_topic_score_gemma":0.003821736,"domain_scores_codex":[0.9998304,0.00001786492,0.00002490374,0.00003470466,0.00007472103,0.00001743995],"domain_scores_gemma":[0.9998721,0.00002583417,0.0000215068,0.00003090625,0.00002867444,0.00002096769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007537309,0.00004420492,0.003149424,0.00008297772,0.00001554801,0.0001714186,0.00006186926,0.0001412853,0.9913051,0.000185786,0.0001854681,0.004581492],"study_design_scores_gemma":[0.00002895749,0.0005190786,0.08239403,0.0000162191,0.00005609895,0.002652233,0.0001625509,0.002766213,0.8934145,0.0001821627,0.01779125,0.0000167305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763126,0.002203072,0.01361112,0.0001172394,0.00005302285,0.0001635783,0.002663539,0.0001889733,0.004686781],"genre_scores_gemma":[0.9756446,0.001372979,0.01043763,0.00005310955,0.00001526685,0.000118943,0.00534517,0.00003291326,0.006979386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00180138,"threshold_uncertainty_score":0.005509257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009858524486321019,"score_gpt":0.2340412081029299,"score_spread":0.2241826836166088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}