{"id":"W2994647402","doi":"10.1128/mbio.02985-19","title":"RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens Enterotoxin","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Necroptosis; Clostridium perfringens; Enterotoxin; Programmed cell death; Microbiology; Apoptosis; Kinase; Necrosis; Virulence; Biology; Chemistry; Cell biology; Biochemistry; Escherichia coli; Bacteria; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003323399,0.0003826754,0.0006214621,0.0002212309,0.0001310588,0.0001042207,0.0002204863,0.0002274357,0.0009942941],"category_scores_gemma":[0.0001056478,0.0003518013,0.0001558428,0.0003468599,0.00006384742,0.00007576814,0.0002605216,0.0005067701,0.001576896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631579,"about_ca_system_score_gemma":0.0001569407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002996446,"about_ca_topic_score_gemma":0.00002148867,"domain_scores_codex":[0.9971346,0.00006873858,0.000428338,0.0007822116,0.0006553453,0.0009307374],"domain_scores_gemma":[0.9981292,0.0001180314,0.00007520031,0.000708947,0.0002026624,0.0007659774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004636318,0.0003713721,0.03528336,0.0001941388,0.00008563351,0.00007780066,0.0002640321,0.000001636545,0.9199437,0.00003128903,0.04246021,0.0008231486],"study_design_scores_gemma":[0.004526887,0.001349296,0.005645898,0.0001078932,0.00008950133,0.00003992695,0.0001943948,0.000128364,0.841985,0.00000571807,0.1455467,0.000380399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877021,0.0009524222,0.00003456781,0.002525992,0.000264526,0.001831785,0.0002733103,0.0001181003,0.006297139],"genre_scores_gemma":[0.9799442,0.0002583104,0.00009054554,0.0009086737,0.0002297344,0.0000713372,0.0001378947,0.000068726,0.01829052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1030865,"threshold_uncertainty_score":0.9999189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466217219561385,"score_gpt":0.2701979060806374,"score_spread":0.2555357338850235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}