{"id":"W2994671347","doi":"10.1089/rej.2019.2263","title":"Intra-Articular Injections of a Whole Blood Clot Secretome, Autologous Conditioned Serum, Have Superior Clinical and Biochemical Efficacy Over Platelet-Rich Plasma and Induce Rejuvenation-Associated Changes of Joint Metabolism: A Prospective, Controlled Open-Label Clinical Study in Chronic Knee Osteoarthritis","year":2019,"lang":"en","type":"article","venue":"Rejuvenation Research","topic":"Periodontal Regeneration and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Osteoarthritis; Synovial fluid; Subclinical infection; Synovitis; Platelet-rich plasma; Whole blood; Internal medicine; Population; Gastroenterology; Platelet activation; Arthritis; Immunology; Platelet; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001444739,0.0007994,0.00124433,0.0005077621,0.0002569146,0.000489032,0.0004809693,0.0007176545,0.001172933],"category_scores_gemma":[0.0007887355,0.0004381141,0.0007406648,0.0003847371,0.001028977,0.0005900341,0.0002256931,0.001212521,0.0002192494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240762,"about_ca_system_score_gemma":0.0003872049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021156,"about_ca_topic_score_gemma":0.0005741765,"domain_scores_codex":[0.9992643,0.000324005,0.00007009091,0.0001227087,0.0001279494,0.00009100087],"domain_scores_gemma":[0.9992187,0.0001950242,0.0002669484,0.00007985663,0.00005517861,0.0001843498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5782754,0.116529,0.004703951,0.001211656,0.0008766177,0.0001898384,0.0002475941,0.0004379664,0.2497142,0.0001295149,0.0003431405,0.04734121],"study_design_scores_gemma":[0.07071758,0.8937027,0.01520613,0.00002123126,0.0003801058,0.0001922662,0.00005304954,0.0003994945,0.01873423,0.000037736,0.000530309,0.00002513103],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979156,0.001363158,0.0002616026,0.00002806512,0.00003954373,0.0002138278,0.00008119929,0.00001109547,0.00008587576],"genre_scores_gemma":[0.9963794,0.001425981,0.0007242556,0.0001050606,0.0001832499,0.0003377892,0.0003129766,0.000005686564,0.000525484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444739,"threshold_uncertainty_score":0.0076406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08291689070498974,"score_gpt":0.4173608293468455,"score_spread":0.3344439386418557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}