{"id":"W2994676763","doi":"10.1053/j.gastro.2019.12.012","title":"Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Cancer Care Ontario","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Cancer Research UK; Wageningen University and Research; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; School of Medicine, New York University; European Commission; Centre Hospitalier Universitaire de Nantes; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Junta de Castilla y León; Conseil Régional des Pays de la Loire; Instituto de Salud Carlos III; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; National Institutes of Health; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Cancerfonden; ZonMw; Centers for Disease Control and Prevention; National Human Genome Research Institute; California Department of Public Health; University of Melbourne; University of Southern California; York University; U.S. Department of Health and Human Services; USC Norris Comprehensive Cancer Center; Memorial Sloan-Kettering Cancer Center; World Cancer Research Fund International; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Kaiser Permanente; Generalitat de Catalunya; Hellenic Health Foundation; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Bundesministerium für Bildung und Forschung; National Institute on Aging; Agency for Healthcare Research and Quality; Association Anne de Bretagne Genetique; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Institut National de la Santé et de la Recherche Médicale","keywords":"Colorectal cancer; Medicine; Cancer; Oncology; Incidence (geometry); Cumulative incidence; Internal medicine; Family history; Population; Cumulative risk; Cohort; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001886699,0.0004605144,0.001129629,0.0002040092,0.00006403344,0.00001441941,0.0002937463,0.0003594483,0.002066761],"category_scores_gemma":[0.0001237224,0.0004054554,0.0001685468,0.0003589932,0.0003836904,0.00006565988,0.0001417359,0.0005318819,0.00002857502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006583134,"about_ca_system_score_gemma":0.0004273299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003527827,"about_ca_topic_score_gemma":0.002337682,"domain_scores_codex":[0.9968198,0.0002591196,0.0006115841,0.0007186551,0.0006000968,0.0009907237],"domain_scores_gemma":[0.9980803,0.0001468081,0.0006064043,0.0004072779,0.0005135744,0.0002456091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006121648,0.0002006067,0.9822179,0.00004336593,0.001497115,0.00004141321,0.00208998,0.00308283,0.003452867,2.695203e-7,0.001163946,0.00008803325],"study_design_scores_gemma":[0.006831553,0.007042518,0.9794911,0.0003273773,0.0005001444,0.00003998297,0.0001512852,0.003587022,0.001774779,0.00001222502,0.00002585845,0.0002161723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956104,0.0001376924,0.00001601204,0.0009897524,0.0006090554,0.001143237,0.001305295,0.00007735645,0.0001112287],"genre_scores_gemma":[0.9977481,0.00006322969,0.0002325712,0.0006953463,0.00006908651,0.0001875621,0.0001327949,0.00008941574,0.0007818521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006841911,"threshold_uncertainty_score":0.9998397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222276896017421,"score_gpt":0.2698386137927707,"score_spread":0.2576158448325965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}