{"id":"W2994676763","doi":"10.1053/j.gastro.2019.12.012","title":"Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Cancer Care Ontario","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Cancer Research UK; Wageningen University and Research; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; School of Medicine, New York University; European Commission; Centre Hospitalier Universitaire de Nantes; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Junta de Castilla y León; Conseil Régional des Pays de la Loire; Instituto de Salud Carlos III; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; National Institutes of Health; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Cancerfonden; ZonMw; Centers for Disease Control and Prevention; National Human Genome Research Institute; California Department of Public Health; University of Melbourne; University of Southern California; York University; U.S. Department of Health and Human Services; USC Norris Comprehensive Cancer Center; Memorial Sloan-Kettering Cancer Center; World Cancer Research Fund International; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Kaiser Permanente; Generalitat de Catalunya; Hellenic Health Foundation; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Bundesministerium für Bildung und Forschung; National Institute on Aging; Agency for Healthcare Research and Quality; Association Anne de Bretagne Genetique; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Institut National de la Santé et de la Recherche Médicale","keywords":"Colorectal cancer; Medicine; Cancer; Oncology; Incidence (geometry); Cumulative incidence; Internal medicine; Family history; Population; Cumulative risk; Cohort; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004133762,0.0004259875,0.0005788719,0.0009595201,0.0004101473,0.0008155781,0.0004028019,0.0006974826,0.006594718],"category_scores_gemma":[0.00295801,0.000326042,0.001330083,0.00153525,0.0003318976,0.0004516052,0.0005838464,0.0009178773,0.0005205559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748477,"about_ca_system_score_gemma":0.0002566888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004815433,"about_ca_topic_score_gemma":0.005741349,"domain_scores_codex":[0.9992861,0.0001536833,0.00007447453,0.0002566771,0.0000849451,0.0001441606],"domain_scores_gemma":[0.9973808,0.0005612656,0.001177166,0.0002774269,0.0001460765,0.0004572043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006858307,0.00002326655,0.9920557,0.00002635232,0.0004705193,0.0003757988,0.00005325716,0.0001052176,0.003099177,0.00008780696,0.0002080458,0.002808991],"study_design_scores_gemma":[0.000009290111,0.0000593057,0.9980595,0.000009197678,0.0001711755,0.0007434683,0.00007598687,0.0001981967,0.0001569943,0.0001196293,0.0003891602,0.000008096753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995053,0.001961339,0.0005392353,0.0002254527,0.00005333535,0.000004560485,0.0008998186,0.000025491,0.001237659],"genre_scores_gemma":[0.9985671,0.0002994351,0.0001522415,0.00003978925,0.00004786144,0.000001849242,0.000417861,0.00001222846,0.0004616047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006594718,"threshold_uncertainty_score":0.02206153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222276896017421,"score_gpt":0.2698386137927707,"score_spread":0.2576158448325965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}