{"id":"W2994706204","doi":"10.1371/journal.pone.0218178","title":"Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"CTGF; Matricellular protein; CYR61; Extracellular matrix; Cell biology; Signal transduction; Transforming growth factor beta; Biology; Transforming growth factor; YAP1; Growth factor; Focal adhesion; Cancer research; Chemistry; Transcription factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001791306,0.000314394,0.0004658223,0.0002092116,0.00009125393,0.00003928217,0.0003522739,0.0003126691,0.0001755975],"category_scores_gemma":[0.0001281531,0.0002982354,0.00007676843,0.0001828189,0.0001202352,0.00006079895,0.0003265581,0.000301588,0.000007361791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002963285,"about_ca_system_score_gemma":0.00005937631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451064,"about_ca_topic_score_gemma":0.00006720924,"domain_scores_codex":[0.9977154,0.0001814591,0.0004160111,0.000668064,0.0005166361,0.0005024663],"domain_scores_gemma":[0.9989669,0.0001119142,0.0001369723,0.0004290327,0.0001909194,0.0001642112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001936479,0.0005697446,0.03482845,0.0005261453,0.00006904012,0.000005410734,0.0005133925,0.000002307061,0.9628896,0.000006106693,0.00004695828,0.0003491976],"study_design_scores_gemma":[0.00153223,0.0004864259,0.03204929,0.0007049303,0.0000230314,0.000002377836,0.0002392221,0.00002015078,0.96451,0.0000368217,0.00007315295,0.0003223786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975121,0.001022238,0.00006177922,0.00004991679,0.00003557683,0.0007271341,0.00008241763,0.00002159045,0.000487254],"genre_scores_gemma":[0.9989119,0.0001758471,0.0004348496,0.00002033347,0.00007625702,0.00004989218,0.0001253485,0.00005605741,0.0001494849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779167,"threshold_uncertainty_score":0.999947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03451767333329805,"score_gpt":0.2678105728132812,"score_spread":0.2332928994799832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}