{"id":"W2994706204","doi":"10.1371/journal.pone.0218178","title":"Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"CTGF; Matricellular protein; CYR61; Extracellular matrix; Cell biology; Signal transduction; Transforming growth factor beta; Biology; Transforming growth factor; YAP1; Growth factor; Focal adhesion; Cancer research; Chemistry; Transcription factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810488,0.0003488282,0.0001419922,0.0001687052,0.0002041615,0.0002061894,0.0001045021,0.0001291546,0.00237735],"category_scores_gemma":[0.0001144191,0.0001163613,0.0002133677,0.0001104432,0.0001780646,0.0001415541,0.0001336776,0.0003690771,0.0002665671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991947,"about_ca_system_score_gemma":0.0002822051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007193965,"about_ca_topic_score_gemma":0.001706194,"domain_scores_codex":[0.9998615,0.00002268486,0.00001087207,0.00002455191,0.00004483732,0.00003560623],"domain_scores_gemma":[0.9999372,0.00001513413,0.00001197811,0.00000771198,0.000006336422,0.0000217462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001097885,0.00001917943,0.0001020105,0.00002777464,0.000002508589,0.00002094693,0.000008550783,0.00002392484,0.9989222,0.00006404224,0.00002871597,0.0006703532],"study_design_scores_gemma":[0.00002037338,0.0002165894,0.002866859,0.000002469993,0.00000842033,0.0001593653,0.00001378538,0.0004674541,0.9949267,0.00001862786,0.001297443,0.000001876285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947819,0.001456399,0.00152615,0.0001203455,0.00003970361,0.00002923931,0.0002439824,0.00004327987,0.001758842],"genre_scores_gemma":[0.9944695,0.0005529618,0.001716544,0.00003931782,0.000008730944,0.00005167413,0.0003855169,0.000008260224,0.002767432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237735,"threshold_uncertainty_score":0.007953048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03451767333329805,"score_gpt":0.2678105728132812,"score_spread":0.2332928994799832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}