{"id":"W2994763235","doi":"10.1021/acs.analchem.9b04803","title":"Electrochemical Quantitation of Supramolecular Excipient@Drug Complexation: A General Assay Strategy Based on Competitive Host Binding with Surface-Immobilized Redox Guest","year":2019,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Supramolecular Chemistry and Complexes","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Universidade de Macau","keywords":"Chemistry; Supramolecular chemistry; Cyclic voltammetry; Combinatorial chemistry; Excipient; Redox; Electrochemistry; Molecule; Competitive binding; Binding constant; Stereochemistry; Organic chemistry; Binding site; Chromatography; Electrode; Physical chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008801801,0.001216353,0.0006745938,0.0007733948,0.000266848,0.0005815005,0.001160794,0.001230868,0.0007547666],"category_scores_gemma":[0.001106767,0.0004039665,0.000312345,0.0005797446,0.0005690907,0.0004190673,0.0005417516,0.00133774,0.0004498387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006176829,"about_ca_system_score_gemma":0.0004002338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007818792,"about_ca_topic_score_gemma":0.001502233,"domain_scores_codex":[0.9988092,0.0002905565,0.00008743579,0.0003383953,0.0003506857,0.000123851],"domain_scores_gemma":[0.9994112,0.000230695,0.0001088352,0.00007493149,0.0001146352,0.00005963836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002240343,0.00002145433,0.0001042269,0.00004848,0.000008795038,0.00001740091,0.00002253867,0.00004863156,0.9980778,0.00008842596,0.00002376346,0.001516123],"study_design_scores_gemma":[0.000003203208,0.00008660536,0.0003353873,0.00000285232,0.000009784558,0.0000504102,0.00001075459,0.001258341,0.9979004,0.00002522442,0.0003117057,0.000005411039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7440424,0.007046023,0.2410308,0.0004749801,0.0002315746,0.0005196502,0.000888903,0.001639019,0.004126602],"genre_scores_gemma":[0.8358024,0.00360959,0.1554069,0.0002793183,0.00007155557,0.0006202114,0.00062989,0.00006427966,0.003515889],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001230868,"threshold_uncertainty_score":0.004654884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097503829721308,"score_gpt":0.2471915005597591,"score_spread":0.2362164622625461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}