{"id":"W2994779054","doi":"10.7554/elife.52649","title":"HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"APOBEC3G; Cytidine deaminase; DNA; CTD; Biophysics; Binding site; Cell biology; Chemistry; Plasma protein binding; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384641,0.0001808092,0.0001141352,0.0001275426,0.0002258974,0.000206364,0.0001787266,0.0003349603,0.0006779684],"category_scores_gemma":[0.0001818809,0.000143805,0.0001261764,0.0001243411,0.0002658577,0.0002002027,0.0001899214,0.0003952555,0.0001882578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000344101,"about_ca_system_score_gemma":0.0002053546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001884014,"about_ca_topic_score_gemma":0.003978474,"domain_scores_codex":[0.9998159,0.00001818613,0.000006575659,0.00005029912,0.00006365599,0.00004541755],"domain_scores_gemma":[0.9999026,0.00002155192,0.00002532973,0.00001106999,0.00001625022,0.0000231414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003518226,0.00001168193,0.0009206585,0.00000924395,0.000004553263,0.00001796696,0.00001504988,0.00007773974,0.9974589,0.00006692024,0.00003323894,0.001348908],"study_design_scores_gemma":[0.00001004567,0.0001441124,0.01016378,0.000003978019,0.000005934562,0.0001543553,0.00004593926,0.002153979,0.9858892,0.0001265256,0.001295495,0.000006785444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957601,0.0004271228,0.002908833,0.00004681609,0.000005591311,0.000008980293,0.00003636166,0.00003070494,0.0007755208],"genre_scores_gemma":[0.9961721,0.000145684,0.002412581,0.00005816263,0.000002280086,0.0000116972,0.00006123417,0.000006316912,0.001129916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884014,"threshold_uncertainty_score":0.003746152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745911253576081,"score_gpt":0.2583113336215632,"score_spread":0.2308522210858024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}