{"id":"W2994805025","doi":"10.1016/j.stem.2019.11.002","title":"High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; University of North Carolina at Chapel Hill; Giannini Foundation of Agricultural Economics; California Institute of Regenerative Medicine; A.P. Giannini Foundation; McGill University; Stanford Maternal and Child Health Research Institute; California Institute for Regenerative Medicine; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis; Biology; Cystic fibrosis transmembrane conductance regulator; Genetic enhancement; Stem cell; Cancer research; Mutation; Airway; Immunology; Gene; Pathology; Cell biology; Genetics; Medicine; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004528366,0.0003501684,0.0004391696,0.0002390394,0.0001915635,0.0003561906,0.0002985411,0.000591123,0.002268543],"category_scores_gemma":[0.0002436764,0.000162477,0.0004163714,0.0001485855,0.0002939911,0.000151647,0.0002356871,0.0008487332,0.0006527033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009449937,"about_ca_system_score_gemma":0.0001635275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325358,"about_ca_topic_score_gemma":0.0005757334,"domain_scores_codex":[0.9996774,0.00006203775,0.00004941734,0.00006388289,0.00009066748,0.00005657756],"domain_scores_gemma":[0.9998204,0.00005543301,0.00003392034,0.00003867663,0.00001834686,0.00003314655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009879355,0.00002924571,0.0002127649,0.00002351239,0.000008099568,0.0000751184,0.00002208262,0.00005959027,0.9980066,0.00008699921,0.00008950646,0.001287738],"study_design_scores_gemma":[0.00006557221,0.0004511348,0.004390992,0.000009299904,0.00003627954,0.001073689,0.00005751252,0.0013424,0.9891022,0.00005360501,0.003408623,0.000008557332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880113,0.0010034,0.008430349,0.0002336251,0.000111107,0.0001271153,0.0008488778,0.0001935002,0.001040873],"genre_scores_gemma":[0.9931976,0.0003741802,0.003303121,0.00009168123,0.00001995406,0.00004784438,0.0009255658,0.00004878808,0.00199118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268543,"threshold_uncertainty_score":0.007589042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297277816959475,"score_gpt":0.2413210541816223,"score_spread":0.2283482760120275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}