{"id":"W2994805025","doi":"10.1016/j.stem.2019.11.002","title":"High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; University of North Carolina at Chapel Hill; Giannini Foundation of Agricultural Economics; California Institute of Regenerative Medicine; A.P. Giannini Foundation; McGill University; Stanford Maternal and Child Health Research Institute; California Institute for Regenerative Medicine; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis; Biology; Cystic fibrosis transmembrane conductance regulator; Genetic enhancement; Stem cell; Cancer research; Mutation; Airway; Immunology; Gene; Pathology; Cell biology; Genetics; Medicine; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000575327,0.0003841237,0.0006788197,0.0005920116,0.00009368044,0.00002916353,0.0003397636,0.0003515517,0.000561084],"category_scores_gemma":[0.00002740404,0.0003531447,0.0001503682,0.001069166,0.00005237862,0.0001546346,0.00021357,0.0007563485,0.001297954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000867163,"about_ca_system_score_gemma":0.0003220611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002530694,"about_ca_topic_score_gemma":0.0004759149,"domain_scores_codex":[0.9956647,0.0004718458,0.0009556829,0.001008934,0.001011409,0.0008874389],"domain_scores_gemma":[0.9977393,0.0004511247,0.0002304105,0.0009785178,0.0002344308,0.0003661893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004264883,0.002812881,0.4427967,0.003270637,0.00004044798,0.0000817832,0.0006196611,0.0006879884,0.5331948,0.00000629004,0.002376344,0.009847631],"study_design_scores_gemma":[0.01210475,0.002970041,0.366101,0.0005227946,0.00006998215,9.501109e-7,0.0002356668,0.004499311,0.6073588,0.00002857552,0.005564311,0.0005438744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946128,0.001559171,0.00009723305,0.00003541878,0.0008789183,0.002038428,0.0001464199,0.0001678679,0.0004637121],"genre_scores_gemma":[0.9925078,0.0001645222,0.000243601,0.0001709339,0.00009694461,0.00008628255,0.0001032102,0.00008841609,0.006538292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0766957,"threshold_uncertainty_score":0.9998921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297277816959475,"score_gpt":0.2413210541816223,"score_spread":0.2283482760120275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}