{"id":"W2994811943","doi":"10.1073/pnas.1913227117","title":"Reactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneurons","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neural dynamics and brain function","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre for Research on Brain Language and Music; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec-Société et Culture; Government of Canada; Centre for Research on Brain, Language and Music","keywords":"Parvalbumin; Neuroscience; Perineuronal net; Interneuron; Auditory cortex; Neuroplasticity; Sensory system; Biology; Inhibitory postsynaptic potential; Period (music); Cortex (anatomy)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006890104,0.0001958791,0.0001339375,0.0001456542,0.00009256817,0.000194792,0.0002014652,0.0001354646,0.0006494295],"category_scores_gemma":[0.00009985363,0.00009361502,0.0001303203,0.00005726721,0.0002743194,0.0001605985,0.0002126948,0.0005161318,0.0001199857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130831,"about_ca_system_score_gemma":0.0001933606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005188349,"about_ca_topic_score_gemma":0.00136909,"domain_scores_codex":[0.99993,0.00000343073,0.000004831677,0.00001900082,0.00001815112,0.00002448079],"domain_scores_gemma":[0.999898,0.00001240553,0.00004267247,0.00001025317,0.000008044167,0.00002867942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003534946,0.00001210328,0.0001368589,0.00001106125,0.000001845639,0.00002452245,0.000008042077,0.00004782563,0.9977514,0.00008440352,0.00001398502,0.001872542],"study_design_scores_gemma":[0.00001100797,0.0002994708,0.01006873,0.000006787821,0.00001356817,0.0001361116,0.00002993548,0.0009762244,0.9874232,0.00008837126,0.0009430408,0.000003657005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950371,0.0004261333,0.003503663,0.00004090725,0.00001986229,0.00001049625,0.00009863637,0.00009943748,0.0007637279],"genre_scores_gemma":[0.9974478,0.0002720225,0.0009502706,0.00002683698,0.000004479258,0.00001932341,0.00006370188,0.00001940583,0.001196024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006494295,"threshold_uncertainty_score":0.00217253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139516933122139,"score_gpt":0.2964366413625386,"score_spread":0.2650414720313172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}