{"id":"W2994814645","doi":"10.1002/adhm.201901176","title":"Double‐Layered M2e‐NA Protein Nanoparticle Immunization Induces Broad Cross‐Protection against Different Influenza Viruses in Mice","year":2019,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Science Foundation","keywords":"Immunogenicity; Viral matrix protein; Ectodomain; Virology; Influenza vaccine; Immunization; Influenza A virus; Immune system; Epitope; Antibody; Virus; Chemistry; Biology; Immunology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557566,0.000727584,0.0003111529,0.0004060976,0.0001226926,0.0002241313,0.0002660801,0.0006643618,0.0007981312],"category_scores_gemma":[0.0001304479,0.0003134443,0.0004119464,0.00009474119,0.0002731599,0.0003309071,0.0002577623,0.0008831132,0.0003231757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409648,"about_ca_system_score_gemma":0.0001705206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003455005,"about_ca_topic_score_gemma":0.0004231139,"domain_scores_codex":[0.9997932,0.00002823544,0.00002060423,0.00006103824,0.0000498288,0.00004711514],"domain_scores_gemma":[0.9998509,0.00001801597,0.00005139046,0.00001995316,0.00002278416,0.00003702847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148778,0.0001013219,0.00006753459,0.00002732154,0.000009351937,0.00001946904,0.00001250761,0.00005868409,0.9987186,0.00006264726,0.00003351981,0.0007401097],"study_design_scores_gemma":[0.00002840584,0.0007736965,0.0009232243,0.000006871795,0.00001940251,0.000105777,0.00000955594,0.0008650554,0.9962242,0.00004299319,0.0009973461,0.000003659781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873311,0.00120678,0.008432422,0.0001846783,0.00009304422,0.00008117752,0.0002697521,0.0002617518,0.002139224],"genre_scores_gemma":[0.9881644,0.0008302815,0.005851459,0.0001755438,0.00002164057,0.00008591708,0.0004951817,0.00004938501,0.004326204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007981312,"threshold_uncertainty_score":0.00267005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09799861813483625,"score_gpt":0.408357633710427,"score_spread":0.3103590155755908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}