{"id":"W2994814645","doi":"10.1002/adhm.201901176","title":"Double‐Layered M2e‐NA Protein Nanoparticle Immunization Induces Broad Cross‐Protection against Different Influenza Viruses in Mice","year":2019,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Science Foundation","keywords":"Immunogenicity; Viral matrix protein; Ectodomain; Virology; Influenza vaccine; Immunization; Influenza A virus; Immune system; Epitope; Antibody; Virus; Chemistry; Biology; Immunology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005248993,0.000354321,0.0007489161,0.0002911595,0.0002315125,0.0001097202,0.0001798736,0.0002237559,0.000115589],"category_scores_gemma":[0.0003013255,0.0003069514,0.00005919573,0.0004698621,0.0001036504,0.000528763,0.000189688,0.0003467087,0.0002634288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005679769,"about_ca_system_score_gemma":0.0001822185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001731143,"about_ca_topic_score_gemma":0.0003067003,"domain_scores_codex":[0.9967796,0.0003189236,0.0009858197,0.0005769026,0.0005413414,0.0007974465],"domain_scores_gemma":[0.9984651,0.00005331721,0.0003184768,0.0005409712,0.0004481861,0.0001739913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004847466,0.000149278,0.01283072,0.001162856,0.00003046769,0.00001014801,0.000881209,0.0001817339,0.9757593,0.0001690069,0.000003081857,0.003974779],"study_design_scores_gemma":[0.006166036,0.0005349088,0.06460444,0.0008402902,0.000006833152,0.000003693434,0.0003028419,0.00001907852,0.9264843,0.0001284531,0.0006396234,0.0002694293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930284,0.0008638697,0.000008871645,0.0005759592,0.000429283,0.004761233,0.00004814662,0.0001923879,0.00009186424],"genre_scores_gemma":[0.9967929,0.0001748669,0.0001992242,0.001587118,0.0001071772,0.000886941,0.00003426591,0.00006896458,0.0001485441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05177372,"threshold_uncertainty_score":0.9999382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09799861813483625,"score_gpt":0.408357633710427,"score_spread":0.3103590155755908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}