{"id":"W2994835831","doi":"10.1128/iai.00787-19","title":"Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection","year":2019,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Streptococcus suis; Inflammation; Biology; Immunology; Disease; Central nervous system; Systemic inflammation; Immune system; Microbiology; Medicine; Pathology; Virulence; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003334628,0.0006676927,0.0004309061,0.0005785986,0.000286748,0.0005546084,0.0002372095,0.0006686373,0.002705855],"category_scores_gemma":[0.0002369215,0.0002730664,0.0003576446,0.0001827574,0.0005053963,0.0004596701,0.0002838003,0.001959311,0.0006376714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004023751,"about_ca_system_score_gemma":0.0004557873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006453512,"about_ca_topic_score_gemma":0.001399601,"domain_scores_codex":[0.9993908,0.0001431257,0.00006253574,0.00008356658,0.0001359368,0.0001840199],"domain_scores_gemma":[0.999606,0.00002486593,0.0001080274,0.00003600987,0.00004645186,0.0001786743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002353352,0.0004012818,0.00111687,0.0001265694,0.00001849956,0.0002900095,0.00006736433,0.0001322894,0.9916112,0.0004609346,0.0003239711,0.003097776],"study_design_scores_gemma":[0.0003674977,0.003453135,0.0366452,0.0001321725,0.0001281486,0.00116358,0.0004435329,0.002936339,0.9472349,0.0006137089,0.006851398,0.00003030415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872159,0.004710792,0.002800568,0.0006793886,0.000223651,0.00009519292,0.000827039,0.000137367,0.003310005],"genre_scores_gemma":[0.9900441,0.001441419,0.001404659,0.0001618324,0.00003695472,0.0001352382,0.0004731319,0.00001805251,0.006284667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002705855,"threshold_uncertainty_score":0.009051919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03126233294751528,"score_gpt":0.279223764178229,"score_spread":0.2479614312307137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}