{"id":"W2994853782","doi":"10.1002/jbmr.3951","title":"Myeloma Cells Down-Regulate Adiponectin in Bone Marrow Adipocytes Via TNF-Alpha","year":2019,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Cancer Institute; British Heart Foundation; Seventh Framework Programme; Blood Cancer UK; Medical Research Council Canada; European Commission; NIHR Oxford Biomedical Research Centre; Bloodwise; National Institute for Health and Care Research; Marie Curie; National Institutes of Health; FP7 People: Marie-Curie Actions; International Myeloma Foundation","keywords":"Adiponectin; Tumor necrosis factor alpha; Bone marrow; Endocrinology; Internal medicine; Alpha (finance); Medicine; Cancer research; Obesity; Insulin resistance; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710557,0.0002539304,0.0003064987,0.0002602842,0.00015704,0.0005433122,0.0001745437,0.000209523,0.001653543],"category_scores_gemma":[0.00009190078,0.0001292087,0.000313705,0.000260654,0.0002508972,0.0002051113,0.0002579703,0.001030091,0.0007186942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395114,"about_ca_system_score_gemma":0.0002405087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000877774,"about_ca_topic_score_gemma":0.001264711,"domain_scores_codex":[0.9998057,0.00003024917,0.00002599289,0.00003311176,0.00006657568,0.00003834604],"domain_scores_gemma":[0.9999039,0.0000152653,0.00002806452,0.00001500576,0.0000174069,0.00002038764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003372226,0.00009434055,0.0003233573,0.00004983953,0.000008707771,0.00006760726,0.0000269445,0.00004284979,0.9967105,0.0001346456,0.0000962787,0.00210763],"study_design_scores_gemma":[0.0001242054,0.0009761432,0.01231124,0.00001856848,0.00006297319,0.0003752612,0.0001459574,0.001183853,0.9761271,0.0001395591,0.008526777,0.000008493707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848691,0.006470053,0.003370903,0.0003913227,0.0002101372,0.00004775372,0.0007270928,0.0001852224,0.003728332],"genre_scores_gemma":[0.9868873,0.002749442,0.002264372,0.0002013843,0.00003402297,0.00005114124,0.0007810445,0.00003423469,0.006997093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001653543,"threshold_uncertainty_score":0.005531669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415358773412006,"score_gpt":0.3155334571383897,"score_spread":0.2913798694042696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}