{"id":"W2994862706","doi":"10.1038/s41467-019-13662-9","title":"Evolution of imprinting via lineage-specific insertion of retroviral promoters","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; NODAI Genome Research Center, Tokyo University of Agriculture; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Tokyo University of Agriculture; Japan Society for the Promotion of Science; National Center for Child Health and Development; Ministry of Education, Culture, Sports, Science and Technology; Government of Canada","keywords":"Genomic imprinting; Biology; Genetics; Germline; Endogenous retrovirus; Gene; Imprinting (psychology); DNA methylation; Allele; Promoter; Lineage (genetic); Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002840691,0.0001873348,0.00009120766,0.0003495597,0.0001404347,0.0003469136,0.0003708972,0.0001842706,0.0006226345],"category_scores_gemma":[0.0002430321,0.0002098559,0.0001647064,0.0001420994,0.0003008446,0.0002076709,0.0005392483,0.0004992492,0.0002645779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003371257,"about_ca_system_score_gemma":0.0002261908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004442385,"about_ca_topic_score_gemma":0.0007937548,"domain_scores_codex":[0.9998254,0.00002818091,0.00001387275,0.00004746618,0.00004984347,0.00003534984],"domain_scores_gemma":[0.999828,0.00003965353,0.00006040798,0.00003868283,0.0000114492,0.00002176032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003822758,0.000007277376,0.001710556,0.00001405568,0.000004658888,0.00008752641,0.00005393029,0.00008718742,0.9922972,0.001260833,0.00001376934,0.004424781],"study_design_scores_gemma":[0.00001434673,0.000197036,0.01588379,0.00001750349,0.00003041266,0.001200056,0.00007460228,0.00287389,0.9714248,0.0005212001,0.007752968,0.000009311763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795673,0.0008128618,0.01576251,0.00007842989,0.00001930605,0.00002735566,0.0001539975,0.0001547216,0.003423578],"genre_scores_gemma":[0.9909427,0.0007065908,0.005156333,0.00003598751,0.000008207147,0.00001558117,0.0002679582,0.00003309926,0.002833749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006226345,"threshold_uncertainty_score":0.002445996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00974776730715178,"score_gpt":0.2656293730605732,"score_spread":0.2558816057534214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}