{"id":"W2994935974","doi":"10.1158/1538-7445.panca19-b46","title":"Abstract B46: Targeting pancreatic cancer organoids with dual BET and CBP/P300 inhibitor NEO2734","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"BET inhibitor; Bromodomain; BRD4; Cancer research; Biomarker; Pancreatic cancer; Histone deacetylase inhibitor; Cancer; Medicine; Pharmacology; Biology; Gene; Internal medicine; Epigenetics; Histone; Genetics; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009089951,0.0002228343,0.0002441425,0.000255753,0.0001173958,0.0002723506,0.0001171404,0.0001820351,0.0009991775],"category_scores_gemma":[0.00006391423,0.00008852432,0.0002278292,0.0002058582,0.0001315817,0.0001162642,0.0001547671,0.0004550263,0.0003040577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002636442,"about_ca_system_score_gemma":0.0001865048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007691394,"about_ca_topic_score_gemma":0.001076683,"domain_scores_codex":[0.9998837,0.00001074491,0.000007590888,0.00003581948,0.0000434908,0.0000185926],"domain_scores_gemma":[0.9999478,0.000008483446,0.00001181654,0.000005586282,0.000006456858,0.00001984769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202817,0.00002693083,0.000326238,0.00001809393,0.000004367462,0.00001904811,0.000005949919,0.0001370304,0.99801,0.00002077201,0.00006493257,0.001246334],"study_design_scores_gemma":[0.00001696925,0.0003973572,0.005847107,0.000002825604,0.0000147459,0.0001263473,0.00002376421,0.001426223,0.9906034,0.00001919982,0.001518854,0.000003087467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934033,0.0008673118,0.002855015,0.00007868274,0.00002228464,0.00004145083,0.001363889,0.0001104459,0.001257697],"genre_scores_gemma":[0.9912752,0.0004678566,0.003511871,0.00006077681,0.000004101306,0.00005290017,0.001875562,0.00001821294,0.002733487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009991775,"threshold_uncertainty_score":0.003342569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02052365006212125,"score_gpt":0.3271277593844102,"score_spread":0.3066041093222889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}