{"id":"W2994967047","doi":"10.1111/apt.15581","title":"Review article: clinical pharmacology of current and investigational hepatitis B virus therapies","year":2019,"lang":"en","type":"review","venue":"Alimentary Pharmacology & Therapeutics","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; HBsAg; Hepatitis B virus; Hepatitis B; Pharmacokinetics; Drug; Internal medicine; Clinical trial; Pharmacology; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007790391,0.0006750659,0.003578703,0.000194048,0.0001038063,0.000007256253,0.0002787253,0.0003274263,0.001284045],"category_scores_gemma":[0.000002899983,0.0005535167,0.0006042515,0.0003243836,0.001115003,0.00009188113,0.0002855155,0.001109003,0.0001867636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612474,"about_ca_system_score_gemma":0.0007620184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173648,"about_ca_topic_score_gemma":0.00003330547,"domain_scores_codex":[0.9951954,0.001342153,0.001930216,0.0007039654,0.0003316356,0.0004965903],"domain_scores_gemma":[0.9971681,0.001092579,0.0009445274,0.0003482959,0.0002107442,0.0002357889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001036107,0.001159191,0.01479906,0.07646553,0.04834339,0.00004627798,0.0001745564,1.165777e-7,0.0004196824,0.00003886536,0.03330225,0.8251474],"study_design_scores_gemma":[0.001356678,0.0005707695,0.0004785568,0.01363203,0.09847185,0.0001040006,0.000002937028,0.0000115648,0.0001699361,0.00002418308,0.8848107,0.000366764],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001522624,0.9894827,0.000002744159,0.001495168,0.003936048,0.003120647,0.000334369,0.00005582866,0.00004989949],"genre_scores_gemma":[0.00005435631,0.9548957,0.0002153314,0.0431698,0.0009310177,0.0003137729,0.0002733515,0.00009050984,0.0000562147],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8515085,"threshold_uncertainty_score":0.9996916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2464467679843872,"score_gpt":0.4991786279890949,"score_spread":0.2527318600047077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}