{"id":"W2994981813","doi":"10.1002/adtp.201900174","title":"A Nanoparticle Platform for Improved Potency, Stability, and Adjuvanticity of Poly(I:C)","year":2019,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Adjuvant; Potency; Immunogenicity; Immune system; Antigen; Antibody; Chemistry; Nucleic acid; Immunology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181099,0.0003098976,0.0001443243,0.0001709993,0.0001151068,0.0002791276,0.0001343088,0.0002622868,0.0006178857],"category_scores_gemma":[0.000125137,0.0001067813,0.0001259486,0.0001275912,0.0001131176,0.0001669071,0.0001793252,0.0002770229,0.0002619964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959298,"about_ca_system_score_gemma":0.0002086882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004574072,"about_ca_topic_score_gemma":0.000533691,"domain_scores_codex":[0.9999075,0.00001231683,0.000007055783,0.0000252647,0.00003049399,0.00001734951],"domain_scores_gemma":[0.9999338,0.000009603982,0.00002141775,0.000006207311,0.00001653543,0.00001235914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001950922,0.0000136121,0.00002610507,0.00001535746,0.000001746219,0.00001495121,0.000003206607,0.0002204475,0.998129,0.00006084738,0.00002380283,0.001471418],"study_design_scores_gemma":[0.000004216583,0.0001194416,0.0002073749,0.000001857625,0.000004894481,0.00004280141,0.000002022375,0.001076213,0.9978046,0.00001253557,0.0007217749,0.000002390613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623689,0.00163475,0.0313655,0.00008912245,0.00004829324,0.0001098274,0.0002113428,0.0002394362,0.003932777],"genre_scores_gemma":[0.9817114,0.0004051489,0.01566335,0.00005694195,0.000008057346,0.00004726258,0.0001610025,0.00002263984,0.001924138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006178857,"threshold_uncertainty_score":0.002147198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010484758200505,"score_gpt":0.2641937248183802,"score_spread":0.2440888772363751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}