{"id":"W2994981813","doi":"10.1002/adtp.201900174","title":"A Nanoparticle Platform for Improved Potency, Stability, and Adjuvanticity of Poly(I:C)","year":2019,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Adjuvant; Potency; Immunogenicity; Immune system; Antigen; Antibody; Chemistry; Nucleic acid; Immunology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204929,0.0001592323,0.0003226315,0.00004720995,0.0000917919,0.000007221348,0.0001493093,0.0001415061,0.0001311442],"category_scores_gemma":[0.00002809309,0.0001355088,0.00008612446,0.00008905878,0.000201188,0.0001527514,0.00004874292,0.0001206845,0.0000189347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001767789,"about_ca_system_score_gemma":0.0000495342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001948917,"about_ca_topic_score_gemma":0.000005708608,"domain_scores_codex":[0.99907,0.00005302865,0.0003106353,0.0002200319,0.00002244294,0.0003238674],"domain_scores_gemma":[0.9990709,0.0003442703,0.0001387477,0.0003381256,0.00009664272,0.00001132357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002086567,0.0001111058,0.0008037238,0.0000331618,0.0001445068,5.317691e-8,0.0004243237,7.950629e-7,0.8600128,0.001122688,8.13571e-7,0.1352594],"study_design_scores_gemma":[0.003497344,0.001039963,0.002226718,0.00002189898,0.00003887605,0.000009958812,0.0004045785,0.00006458428,0.9622885,0.00140779,0.02882839,0.0001714059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791983,0.01861774,0.0008115456,0.0001647765,0.0003583083,0.0006359582,0.00005088077,0.00004121658,0.0001212246],"genre_scores_gemma":[0.9975108,0.0005553438,0.0007747072,0.0002802003,0.00000453933,0.00002009063,0.00001599346,0.00002254279,0.0008157733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.135088,"threshold_uncertainty_score":0.5525888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010484758200505,"score_gpt":0.2641937248183802,"score_spread":0.2440888772363751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}