{"id":"W2994983323","doi":"10.1101/871350","title":"Overexpression of Mig-6 in Limb Mesenchyme Leads to Accelerated Osteoarthritis in Mice","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Osteoarthritis; Cartilage; SOX9; Immunohistochemistry; Mesenchyme; Pathology; Articular cartilage; Phenotype; Medicine; Knockout mouse; Anatomy; Biology; Gene expression; Internal medicine; Gene; Receptor; Epithelium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004175884,0.0007429424,0.0004410536,0.001294581,0.000239924,0.0004999114,0.0004848895,0.0009172086,0.002861611],"category_scores_gemma":[0.0001590135,0.0005802147,0.0007445428,0.0003100256,0.0004848805,0.0003056483,0.0004396036,0.001341934,0.001238442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004709543,"about_ca_system_score_gemma":0.0003580221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008933988,"about_ca_topic_score_gemma":0.00135412,"domain_scores_codex":[0.999405,0.000085964,0.00009162714,0.0001364777,0.0001654216,0.0001155321],"domain_scores_gemma":[0.999525,0.00003682731,0.0001942829,0.00004692449,0.00002583604,0.0001710852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127081,0.00004680629,0.0001535816,0.00002569373,0.000006054508,0.0000617925,0.000009477489,0.00004284121,0.9989325,0.00008176501,0.00003118667,0.0004812267],"study_design_scores_gemma":[0.00008701732,0.0009023185,0.009284127,0.00002383154,0.00005276594,0.0007546484,0.00004346617,0.001262192,0.9844927,0.0001044122,0.002979475,0.00001309237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846067,0.001986349,0.007495773,0.000329863,0.0001086584,0.0001081606,0.002206028,0.0006998105,0.002458591],"genre_scores_gemma":[0.97411,0.001621371,0.007636567,0.0002392205,0.00004223964,0.0001527663,0.001702919,0.0001898391,0.01430498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002861611,"threshold_uncertainty_score":0.009573042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761139605269994,"score_gpt":0.2460475472935531,"score_spread":0.2284361512408531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}