{"id":"W2994986613","doi":"10.1039/c9an02122a","title":"Ratiometric fluorescent sensing of the parallel G-quadruplex produced by PS2.M: implications for K<sup>+</sup>detection","year":2019,"lang":"en","type":"article","venue":"The Analyst","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fluorescence; Antiparallel (mathematics); Biosensor; Chemistry; Hemin; Cationic polymerization; G-quadruplex; Coumarin; Aptamer; Photochemistry; Combinatorial chemistry; Topology (electrical circuits); Heme; DNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865987,0.0001226002,0.0001630956,0.00007549363,0.0001674985,0.00001843893,0.0002202785,0.00008053726,9.410533e-7],"category_scores_gemma":[0.0001007569,0.00007086775,0.0002177436,0.0006443731,0.00007933973,0.000003738994,0.00006775567,0.00006796875,0.000001374152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002011588,"about_ca_system_score_gemma":0.00002385582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003073926,"about_ca_topic_score_gemma":0.00001768006,"domain_scores_codex":[0.9991241,0.00007677975,0.0002429155,0.0002871876,0.0001061649,0.0001629174],"domain_scores_gemma":[0.9987853,0.00002857477,0.0001980832,0.0007679143,0.0001964502,0.00002369515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003502929,0.00002709771,0.0005849037,0.0000102513,0.0001048265,1.199616e-8,0.00001355211,0.0003765055,0.9930181,0.00002831548,0.001038732,0.00476267],"study_design_scores_gemma":[0.0001800622,0.00009389924,0.000779306,0.000007309262,0.0001339374,0.000003235497,0.00005962774,0.004742154,0.988543,0.0001220038,0.005220992,0.0001144605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650429,0.0002513629,0.03237342,0.001551789,0.00003185617,0.0006186558,0.0000437108,0.00002368204,0.00006254618],"genre_scores_gemma":[0.9978828,0.00006377138,0.001283973,0.0001655622,0.00008896524,0.00001034821,0.00007786394,0.00001435089,0.0004123301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03283986,"threshold_uncertainty_score":0.2889903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065626317847414,"score_gpt":0.2680844947192709,"score_spread":0.2574282315407967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}