{"id":"W2995004100","doi":"10.1097/ccm.0000000000004097","title":"Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*","year":2019,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute; University of Manitoba; University of Toronto; St. Michael's Hospital; Niagara Health System; William Osler Health System","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Epigenome; Medicine; Methylation; Sepsis; Biology; Immunology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005999746,0.0003376028,0.0002957608,0.0002679139,0.0004371798,0.000229813,0.0001954409,0.0003744562,0.000897504],"category_scores_gemma":[0.0010643,0.0001695577,0.0002465702,0.0002474543,0.0003237521,0.0001687411,0.0004225653,0.0003471258,0.0001047681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754327,"about_ca_system_score_gemma":0.0004457713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426924,"about_ca_topic_score_gemma":0.001586197,"domain_scores_codex":[0.9997264,0.0001163724,0.00001148036,0.00007609142,0.00002996745,0.00003975863],"domain_scores_gemma":[0.9993594,0.0001264413,0.000135978,0.00008241149,0.00009102333,0.0002048236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01519884,0.002781274,0.8878574,0.0002044963,0.0002581953,0.001060233,0.001363412,0.0002610438,0.07076579,0.0001144576,0.0005450337,0.01958979],"study_design_scores_gemma":[0.0003892701,0.01271239,0.9825401,0.000009865034,0.0001098931,0.0008478117,0.0003816712,0.0003418893,0.001993927,0.00007581583,0.0005836228,0.00001372362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996299,0.00005415304,0.0001354105,0.00001278396,0.000001689031,0.00002971236,0.00007875037,0.000001477534,0.00005628609],"genre_scores_gemma":[0.999334,0.00004807961,0.0002470963,0.0000366938,0.000008732073,0.00004455751,0.000162864,0.000001674947,0.0001162376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426924,"threshold_uncertainty_score":0.003173053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03138492248693531,"score_gpt":0.3497776366390193,"score_spread":0.318392714152084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}