{"id":"W2995004100","doi":"10.1097/ccm.0000000000004097","title":"Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*","year":2019,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute; University of Manitoba; University of Toronto; St. Michael's Hospital; Niagara Health System; William Osler Health System","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Epigenome; Medicine; Methylation; Sepsis; Biology; Immunology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005371289,0.000187748,0.0003751485,0.0001801848,0.00003033717,0.000008281247,0.0001584021,0.0001272381,0.0000604216],"category_scores_gemma":[0.00188722,0.0001682084,0.00003203005,0.0002768654,0.0001598927,0.000007393008,0.00009028444,0.0001836291,0.000004626565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003426429,"about_ca_system_score_gemma":0.00007128146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000113216,"about_ca_topic_score_gemma":0.0002043421,"domain_scores_codex":[0.9979918,0.0002832475,0.0005786831,0.0004899474,0.0003505819,0.0003057244],"domain_scores_gemma":[0.9989719,0.0002249767,0.00004592579,0.0003618865,0.0002996541,0.00009560067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000274338,0.0006913315,0.2435831,0.0006327544,0.00001273644,0.00001608311,0.001588835,0.0002440807,0.7489966,0.0007482358,0.000006539958,0.003205403],"study_design_scores_gemma":[0.007884441,0.02770549,0.2565795,0.0007338692,0.0001501104,0.00000636877,0.04829709,0.0007089105,0.6536111,0.003146793,0.0002707013,0.0009056414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992556,0.004633831,0.0003630803,0.0003562687,0.0002774311,0.0007492346,0.000008498705,0.000008037819,0.001047603],"genre_scores_gemma":[0.9990909,0.00005122523,0.0004491663,0.00006245454,0.0001546123,0.00007237858,0.00007296262,0.00002590239,0.00002039485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09538545,"threshold_uncertainty_score":0.6859341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03138492248693531,"score_gpt":0.3497776366390193,"score_spread":0.318392714152084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}