{"id":"W2995022068","doi":"10.1101/2019.12.20.884338","title":"Translational profiling of macrophages infected with <i>Leishmania donovani</i> identifies mTOR- and eIF4A-sensitive immune-related transcripts","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Science for Life Laboratory","keywords":"Biology; Leishmania donovani; PI3K/AKT/mTOR pathway; EIF4E; eIF4A; Messenger RNA; Mechanistic target of rapamycin; Polysome; Protein biosynthesis; Translation (biology); Cell biology; Amastigote; Molecular biology; RNA; Visceral leishmaniasis; Signal transduction; Gene; Parasite hosting; Immunology; Leishmania; Leishmaniasis; Genetics; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119812,0.0002369095,0.0001666666,0.0002319284,0.0001272733,0.0002275262,0.00008108168,0.0001398142,0.0007016995],"category_scores_gemma":[0.00008623824,0.0001077915,0.0002125501,0.0001892841,0.0001514792,0.00008444676,0.0001303048,0.0002540636,0.0003419065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001253779,"about_ca_system_score_gemma":0.0001030308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030237,"about_ca_topic_score_gemma":0.0005005861,"domain_scores_codex":[0.9999213,0.00001010068,0.000004674811,0.00002499433,0.00001943919,0.00001952549],"domain_scores_gemma":[0.9999356,0.00001292041,0.00001883926,0.000005021184,0.0000151929,0.00001248216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007499011,0.000003836139,0.0002974616,0.00001896716,0.000002239385,0.00001393929,0.000007059575,0.00001414644,0.9992359,0.00001157951,0.00001506387,0.0003047678],"study_design_scores_gemma":[0.00001160942,0.0003774218,0.03302835,0.00001205629,0.00003033026,0.0002226037,0.00009912641,0.000961653,0.9631075,0.00005428153,0.002086745,0.000008386239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932544,0.0009951704,0.002621087,0.00006391446,0.00002255547,0.00002717991,0.001935457,0.00006573517,0.001014583],"genre_scores_gemma":[0.9878664,0.001071852,0.004983443,0.0001425265,0.00002222613,0.00007215552,0.003651942,0.00005875395,0.002130522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007016995,"threshold_uncertainty_score":0.00234741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386477779752826,"score_gpt":0.2394504189697888,"score_spread":0.2255856411722606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}