{"id":"W2995022330","doi":"10.1136/gutjnl-2019-319057","title":"Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis","year":2019,"lang":"en","type":"article","venue":"Gut","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Toronto Liver Centre; Toronto Western Hospital","funders":"Canadian Liver Foundation; Stichting voor Lever- en Maag-Darm Onderzoek; Intercept Pharmaceuticals; Gilead Sciences; Dr. Falk Pharma; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Ursodeoxycholic acid; Medicine; Number needed to treat; Internal medicine; Primary biliary cirrhosis; Gastroenterology; Hazard ratio; Liver transplantation; Transplantation; Confidence interval; Surgery; Relative risk","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006398142,0.0001341182,0.0002057845,0.00008464682,0.00002415468,0.00001647383,0.00007927078,0.00004832469,0.0008003507],"category_scores_gemma":[0.000004736995,0.00008819095,0.00004778402,0.0002201926,0.000007979558,0.0001329182,0.00001314302,0.0001017154,0.0005219337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047238,"about_ca_system_score_gemma":0.00009050453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311998,"about_ca_topic_score_gemma":0.00005376809,"domain_scores_codex":[0.9992324,0.00004446408,0.000129109,0.0002143044,0.000179947,0.0001997888],"domain_scores_gemma":[0.9994576,0.00002415035,0.00002078272,0.0002961543,0.00003577558,0.0001655275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02871235,0.003289479,0.8061358,0.0009542357,0.0002340714,0.000830918,0.02142227,0.00005214902,0.07152883,0.00004171541,0.004873377,0.06192478],"study_design_scores_gemma":[0.00340454,0.0009572817,0.9871041,0.0002737036,0.00006376264,0.00009341623,0.0001770144,0.000006795731,0.00626678,0.000004507585,0.001491971,0.0001561074],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927862,0.0001408683,0.00003636926,0.0004894311,0.00004552766,0.001142463,0.00003427464,0.00003701752,0.005287791],"genre_scores_gemma":[0.9903757,0.0005248517,0.000549803,0.004570593,0.00005335055,0.00007023398,0.00009518526,0.00002457356,0.003735717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1809683,"threshold_uncertainty_score":0.8763279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843986216430232,"score_gpt":0.2726429477647892,"score_spread":0.2542030856004869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}