{"id":"W2995063435","doi":"10.1101/2019.12.15.876672","title":"Microbiome Determinants and Physiological Effects of the Benzoate-Hippurate Microbial-Host Co-Metabolic Pathway","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"FP7 People: Marie-Curie Actions; NIHR Imperial Biomedical Research Centre; Vlaamse regering; Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk Fonden; Fonds Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Medical Research Council; Novo Nordisk; National Institute for Health and Care Research","keywords":"Gut flora; Metabolomics; Context (archaeology); Insulin resistance; Urine; Chemistry; Metabolome; Biology; Internal medicine; Endocrinology; Biochemistry; Diabetes mellitus; Bioinformatics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426242,0.0003180832,0.0003613349,0.0003951679,0.0002945777,0.0006393678,0.0001133696,0.0002779194,0.001215414],"category_scores_gemma":[0.0004138784,0.0001929032,0.0002998621,0.0004567452,0.0002374432,0.0002436009,0.000515444,0.0003023311,0.0001591612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936289,"about_ca_system_score_gemma":0.0003971801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00249102,"about_ca_topic_score_gemma":0.003309685,"domain_scores_codex":[0.9997298,0.00007628983,0.00001480805,0.00007870951,0.00005055071,0.00004989121],"domain_scores_gemma":[0.9996431,0.00003525106,0.0001816956,0.00002326547,0.00004602417,0.00007070044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003525224,0.0001426728,0.3478563,0.0003151239,0.000418102,0.0001788996,0.0002225172,0.000352549,0.6369745,0.0002651841,0.0001861765,0.009562866],"study_design_scores_gemma":[0.0000179213,0.0004854132,0.9722933,0.00002736331,0.0001421138,0.0002641953,0.0002883968,0.0009463672,0.02440954,0.0002096697,0.0009004367,0.00001528616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968001,0.00101979,0.0009340055,0.00007060379,0.000006149085,0.00001323413,0.0008062127,0.00001035971,0.0003394502],"genre_scores_gemma":[0.9979081,0.0003597824,0.0009201544,0.00003697492,0.000005451409,0.00001257856,0.0004044849,0.000005842331,0.0003466379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249102,"threshold_uncertainty_score":0.004952967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00881449680627616,"score_gpt":0.2138606002550653,"score_spread":0.2050461034487891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}