{"id":"W2995066388","doi":"10.1089/hum.2019.225","title":"Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Dravet Syndrome Foundation","keywords":"Dravet syndrome; Epilepsy; Sodium channel; Medicine; Transgene; Neuroscience; Internal medicine; Endocrinology; Biology; Gene; Genetics; Chemistry; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873977,0.0002395068,0.0003449716,0.000202823,0.0001280498,0.0000429293,0.0005063495,0.00007982912,0.0003050312],"category_scores_gemma":[0.00001535883,0.0002059035,0.00006964894,0.0002640918,0.0003697352,0.0002118253,0.0001690814,0.0002813304,0.00003187405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002538122,"about_ca_system_score_gemma":0.00008575928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004439619,"about_ca_topic_score_gemma":0.00001267706,"domain_scores_codex":[0.9973962,0.0003897474,0.0003656567,0.0008011796,0.0005119887,0.0005352392],"domain_scores_gemma":[0.9991327,0.00006550964,0.00008428545,0.0005476872,0.00003448856,0.0001353132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005479391,0.0003555948,0.01532585,0.00001040488,0.000008114808,0.00009338257,0.0006330612,0.0006220798,0.9821,0.00007719026,0.000006267326,0.0002201538],"study_design_scores_gemma":[0.002009643,0.0009253265,0.03238025,0.000003707186,0.000002596794,0.00001796612,0.000007251037,0.003157383,0.961008,0.0002659509,0.0000195861,0.0002023924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987109,0.0001545193,0.00001273484,0.00005991403,0.000144474,0.0007922876,0.00004709782,0.00003745165,0.00004059485],"genre_scores_gemma":[0.9958552,0.001735059,0.00001312202,0.00128693,0.00003060619,0.00008157649,9.654984e-7,0.00003612914,0.0009604189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02109201,"threshold_uncertainty_score":0.8396503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308050061926855,"score_gpt":0.363080674129986,"score_spread":0.2322756679373005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}