{"id":"W2995066388","doi":"10.1089/hum.2019.225","title":"Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Dravet Syndrome Foundation","keywords":"Dravet syndrome; Epilepsy; Sodium channel; Medicine; Transgene; Neuroscience; Internal medicine; Endocrinology; Biology; Gene; Genetics; Chemistry; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002745368,0.0008674548,0.0006568738,0.0009200523,0.0002451197,0.0003150128,0.0005149441,0.0007610901,0.001616082],"category_scores_gemma":[0.0001989645,0.0002691058,0.0005505264,0.0002351796,0.0004747267,0.0003299192,0.0003274135,0.001340901,0.0004705828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028464,"about_ca_system_score_gemma":0.0003273027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005138585,"about_ca_topic_score_gemma":0.0008807309,"domain_scores_codex":[0.9995822,0.00006552844,0.00004792353,0.0001134697,0.0001226877,0.00006817494],"domain_scores_gemma":[0.9996921,0.0000225994,0.0001137487,0.00003405146,0.00002053122,0.0001170855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002782836,0.0002203267,0.000200947,0.0000331004,0.00001264309,0.0002551799,0.00003609424,0.00009806363,0.9965848,0.0002429036,0.0001055141,0.001932282],"study_design_scores_gemma":[0.000472455,0.007332501,0.01101315,0.00005389578,0.00009468282,0.00344931,0.0001149377,0.002800154,0.9683542,0.0003472472,0.005923617,0.00004388743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913584,0.001133135,0.003391223,0.0003470501,0.0001293833,0.0001329979,0.001163154,0.0003058127,0.002038782],"genre_scores_gemma":[0.9822999,0.001786362,0.004132858,0.0002817055,0.00004884115,0.0003800509,0.001672156,0.0001467648,0.009251409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001616082,"threshold_uncertainty_score":0.00540638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308050061926855,"score_gpt":0.363080674129986,"score_spread":0.2322756679373005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}